BVES
| Gene Symbol | BVES |
|---|---|
| Entrez Gene | 11149 |
| Alt Symbol | HBVES, POP1, POPDC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | blood vessel epicardial substance |
| Other Description | popeye domain containing 1|popeye domain-containing protein 1|popeye protein 1 |
| Swissprots | E1P5D8 Q9HBV0 Q8IWC6 Q5T550 A8K1R4 Q8NE79 Q5T551 Q9UNG6 |
| Accessions | EAW48430 EAW48431 EAW48432 Q8NE79 AF204172 AAG23405 AK289979 BAF82668 BC034425 AAH34425 BC040502 AAH40502 HQ447848 ADQ32332 XM_011535398 XP_011533700 NM_001199563 NP_001186492 NM_007073 NP_009004 NM_147147 NP_671488 |
| Function | Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. {ECO:0000269|PubMed:16188940}. |
| Subcellular Location | Lateral cell membrane {ECO:0000269|PubMed:16188940}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. {ECO:0000250}. |
| Tissue Specificity | Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. {ECO:0000269|PubMed:10441744, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:16188940}. |
BVES CRISPR/Cas9 KO Plasmid (h) - sc-403698 from Santa Cruz Biotechnology
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BVES HDR Plasmid (h) - sc-403698-HDR from Santa Cruz Biotechnology
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BVES Double Nickase Plasmid (h) - sc-403698-NIC from Santa Cruz Biotechnology
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BVES Double Nickase Plasmid (h2) - sc-403698-NIC-2 from Santa Cruz Biotechnology
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BVES CRISPR Activation Plasmid (h) - sc-403698-ACT from Santa Cruz Biotechnology
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BVES CRISPR Activation Plasmid (h2) - sc-403698-ACT-2 from Santa Cruz Biotechnology
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BVES Lentiviral Activation Particles (h) - sc-403698-LAC from Santa Cruz Biotechnology
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BVES Lentiviral Activation Particles (h2) - sc-403698-LAC-2 from Santa Cruz Biotechnology
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BVES siRNA (h) - sc-60295 from Santa Cruz Biotechnology
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BVES shRNA Plasmid (h) - sc-60295-SH from Santa Cruz Biotechnology
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BVES shRNA (h) Lentiviral Particles - sc-60295-V from Santa Cruz Biotechnology
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BVES RNAi - H00011149-R02 from Novus Biologicals
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MISSION® esiRNA - EHU076801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4124 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4124 from Sigma-Aldrich
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BVES siRNA (Human) - CRH7631 from Cohesion Biosciences
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BVES RNAi - H00011149-R01 from Novus Biologicals
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BVES - MBS8232948 from MyBioSource
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shRNA set against Human BVES (NM_007073.4) - SHH248498 from Creative biogene
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Human BVES siRNA - orb268133 from Biorbyt
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BVES shRNA Plasmid (Human) - CHH7631 from Cohesion Biosciences
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BVES miRNA 3'UTR clone - MiUTR4H-TG00879 from Creative biogene
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