| Gene Symbol |
BVES
|
| Entrez Gene |
11149
|
| Alt Symbol |
HBVES, POP1, POPDC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
blood vessel epicardial substance
|
| Other Description |
popeye domain containing 1|popeye domain-containing protein 1|popeye protein 1
|
| Swissprots |
E1P5D8 Q9HBV0 Q8IWC6 Q5T550 A8K1R4 Q8NE79 Q5T551 Q9UNG6
|
| Accessions |
EAW48430 EAW48431 EAW48432 Q8NE79 AF204172 AAG23405 AK289979 BAF82668 BC034425 AAH34425 BC040502 AAH40502 HQ447848 ADQ32332 XM_011535398 XP_011533700 NM_001199563 NP_001186492 NM_007073 NP_009004 NM_147147 NP_671488
|
| Function |
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. {ECO:0000269|PubMed:16188940}.
|
| Subcellular Location |
Lateral cell membrane {ECO:0000269|PubMed:16188940}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. {ECO:0000269|PubMed:10441744, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:16188940}.
|
