| Gene Symbol | DOK5 |
|---|---|
| Entrez Gene | 55816 |
| Alt Symbol | C20orf180, IRS-6, IRS6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | docking protein 5 |
| Other Description | downstream of tyrosine kinase 5|insulin receptor substrate 6 |
| Swissprots | Q9BZ24 Q5TE53 Q8TEW7 Q9P104 Q5T7Y0 Q9Y411 Q96H13 Q9NQF4 |
| Accessions | EAW75570 EAW75571 Q9P104 AF132732 AAF66443 AF466368 AAL74194 AI822030 AK313222 AL050069 CAB43255 BC008992 AAH08992 BG212868 BI758267 BI916998 CN427887 DA161365 XM_011528903 XP_011527205 XM_011528904 XP_011527206 NM_001294161 NP_001281090 NM_018431 NP_060901 NM_177959 NP_808874 |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| Tissue Specificity | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}. |
docking protein 5, ELISA Kit - MBS9328709 from MyBioSource
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Docking Protein 5 (DOK5), ELISA Kit - MBS9312413 from MyBioSource
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Human DOK5 ELISA Kit - E012255 from Biobool
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anti-DOK5 antibody - ARG63676 from Arigo Biolaboratories
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