| Gene Symbol |
DOK5
|
| Entrez Gene |
55816
|
| Alt Symbol |
C20orf180, IRS-6, IRS6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
docking protein 5
|
| Other Description |
downstream of tyrosine kinase 5|insulin receptor substrate 6
|
| Swissprots |
Q9BZ24 Q5TE53 Q8TEW7 Q9P104 Q5T7Y0 Q9Y411 Q96H13 Q9NQF4
|
| Accessions |
EAW75570 EAW75571 Q9P104 AF132732 AAF66443 AF466368 AAL74194 AI822030 AK313222 AL050069 CAB43255 BC008992 AAH08992 BG212868 BI758267 BI916998 CN427887 DA161365 XM_011528903 XP_011527205 XM_011528904 XP_011527206 NM_001294161 NP_001281090 NM_018431 NP_060901 NM_177959 NP_808874
|
| Function |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
|
| Tissue Specificity |
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}.
|