| Gene Symbol |
SGPP1
|
| Entrez Gene |
81537
|
| Alt Symbol |
SPPase1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate phosphatase 1
|
| Other Description |
hSPP1|hSPPase1|sphingosine-1-phosphatase 1|spp1
|
| Swissprots |
Q9H189 Q9BX95 B2RAH0
|
| Accessions |
EAW80834 Q9BX95 AF349315 AAK26660 AJ293294 CAC17772 AK314188 BAG36867 BC063839 AAH63839 BC070060 AAH70060 HY008514 XM_006720264 XP_006720327 NM_030791 NP_110418
|
| Function |
Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels. {ECO:0000269|PubMed:12815058}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12815058}; Multi-pass membrane protein {ECO:0000269|PubMed:12815058}.
|
| Tissue Specificity |
Ubiquitous, with the strongest level in placenta and kidney. {ECO:0000269|PubMed:12815058}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|