SGPP1

Gene Symbol SGPP1
Entrez Gene 81537
Alt Symbol SPPase1
Species Human
Gene Type protein-coding
Description sphingosine-1-phosphate phosphatase 1
Other Description hSPP1|hSPPase1|sphingosine-1-phosphatase 1|spp1
Swissprots Q9H189 Q9BX95 B2RAH0
Accessions EAW80834 Q9BX95 AF349315 AAK26660 AJ293294 CAC17772 AK314188 BAG36867 BC063839 AAH63839 BC070060 AAH70060 HY008514 XM_006720264 XP_006720327 NM_030791 NP_110418
Function Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels. {ECO:0000269|PubMed:12815058}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12815058}; Multi-pass membrane protein {ECO:0000269|PubMed:12815058}.
Tissue Specificity Ubiquitous, with the strongest level in placenta and kidney. {ECO:0000269|PubMed:12815058}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SPPase1 (D-15) - sc-55303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPPase1 (K-16) - sc-55306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPPase1 (K-16): sc-55306. Western blot analysis of SPPase1 expression in EOC 20 whole cell lysate.

Anti-sphingosine-1-phosphate phosphatase 1 antibody - ab129253 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab129253 stained JEG3 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab129253 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-sphingosine-1-phosphate phosphatase 1 antibody - ab108435 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody - LS-C26800 from LifeSpan Bioscience

Prices $480.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa12-42, AP) - LS-C240718 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa12-42, APC) - LS-C240719 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa12-42, Biotin) - LS-C240720 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa12-42, FITC) - LS-C240721 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa12-42, PE) - LS-C240722 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa12-42, Azide-free, HRP) - LS-C248145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa12-42) - LS-C325069 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPP1 Antibody (aa13-42) IHC-plus™ - LS-B10202 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SGPP1 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SGPP1 Antibody (aa287-336) IHC-plus™ - LS-B11945 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

SGPP1 Antibody - NBP1-91353 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

SGPP1 Antibody - NBP2-13303 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SGPP1 Antibody [NBP2-13303] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

Anti-SGPP1 antibody produced in rabbit - HPA053149 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SGPP1:<B>Cat. No. HPA053149</B>: Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

ANTI-SGPP1 (N-TERM) antibody produced in rabbit - SAB1301466 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>SGPP1 (N-term): <B>Cat. No. SAB1301466</B>: SGPP1 in Human placenta tissue with SGPP1 antibody (N-term) at 12.5 μg/mL.

SGPP1 antibody - middle region (ARP49967_P050) - ARP49967_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SGPP1-Antibody-N-term - AP13228a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SGPP1 Antibody (N-term) (Cat. #AP13228a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SGPP1 antibody detected the SGPP1 protein (arrow).

Osteopontin antibody - GTX19548 from GeneTex

Host Rabbit
Clonality Polyclonal

SGPP1 Antibody - N-terminal region (OAAB09534) - OAAB09534 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SGPP1 antibody - 70R-8844 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SPP1 Antibody - abx032869 from Abbexa

Host Rabbit
Clonality Polyclonal

SPP1 antibody - abx011873 from Abbexa

Host Mouse
Clonality Monoclonal
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