PACSIN2

Gene Symbol PACSIN2
Entrez Gene 11252
Alt Symbol SDPII
Species Human
Gene Type protein-coding
Description protein kinase C and casein kinase substrate in neurons 2
Other Description cytoplasmic phosphoprotein PACSIN2|protein kinase C and casein kinase substrate in neurons protein 2|syndapin 2|syndapin II|syndapin-2|syndapin-II|syndapin2
Swissprots Q9UNF0 Q9Y4V2 Q96HV9 O95921 Q9NPN1 Q9H0D3
Accessions EAW73277 EAW73278 Q9UNF0 AF128536 AAD41781 AL136845 CAB66779 AL389984 CAB97538 AY007086 BC008037 AAH08037 BI964045 CR456536 CAG30422 CR533523 CAG38554 CU013136 CAK54567 CU013424 CAK54866 DQ892911 ABM83837 DQ896161 ABM87160 XM_005261319 XP_005261376 XM_011529846 XP_011528148 XM_011529847 XP_011528149 XM_011529848 XP_011528150 XM_011529849 XP_011528151 XM_011529850 XP_011528152 XM_011529851 XP_011528153 XM_011529852 XP_011528154 XM_011529853 XP_011528155 NM_001184970 NP_001171899 NM_001184971 NP_001171900 NM_007229 NP_009160
Function Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000250}. Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}.

PACSIN2 (F-12) - sc-390136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PACSIN2 (F-12): sc-390136. Western blot analysis of PACSIN2 expression in SHP-77 (A), F9 (B), SK-N-MC (C) and IMR-32 (D) whole cell lysates.

PACSIN2 (M-19) - sc-10417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PACSIN2 (M-19): sc-10417. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic staining.

PACSIN2 (H-146) - sc-366059 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PACSIN2 (K-16) - sc-10415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PACSIN2 antibody - ab37615 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with the primary antibody at 1/50, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-PACSIN2 antibody - ab118330 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-PACSIN2 antibody (ab118330) at 5 µg/ml + Recombinant immunogen at 0.2 µgdeveloped using the ECL technique

Anti-PACSIN2 antibody - ab172646 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PACSIN2 antibody (ab172646) at 1 µg/mlLane 1 : PACSIN2-transfected 293T cell line lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L)-HRP at 1/7500 dilutiondeveloped using the ECL technique

Anti-PACSIN2 Antibody (aa400-450) IHC-plus™ - LS-B1787 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PACSIN2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1787 concentration 10 ug/ml.

Anti-PACSIN2 Antibody (aa342-371) - LS-C101183 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PACSIN2 Antibody (C-Terminus, AP) - LS-C226082 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACSIN2 Antibody (C-Terminus, Biotin) - LS-C226085 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACSIN2 Antibody (C-Terminus, FITC) - LS-C226086 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACSIN2 Antibody (C-Terminus, APC) - LS-C226084 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACSIN2 Antibody (C-Terminus, Azide-free, HRP) - LS-C226087 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACSIN2 Antibody (C-Terminus, PE) - LS-C226088 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACSIN2 Antibody (C-Terminus, Azide-free) - LS-C328127 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACSIN2 Antibody (clone 3D6) - LS-C134035 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D6
Immunoperoxidase of monoclonal antibody to PACSIN2 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]

PACSIN2 Antibody - NBP2-24481 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PACSIN2 Antibody [NBP2-24481] - Analysis of PACSIN2 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse brain lysate and 4) rat brain lysateusing NBP2-24481 at 0.05 ug/ml.

PACSIN2 Antibody - NBP2-29921 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PACSIN2 Antibody [NBP2-29921] - Daudi cell line and mouse brain lysates (35ug/lane).This demonstrates the PACSIN2 antibody detected

PACSIN2 Antibody - NBP2-13723 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PACSIN2 Antibody - NBP1-32827 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PACSIN2 Antibody (3D6) - H00011252-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D6
Immunocytochemistry/Immunofluorescence: PACSIN2 Antibody (3D6) [H00011252-M05] - Analysis of monoclonal antibody to PACSIN2 on HeLa cell. Antibody concentration 10 ug/ml

PACSIN2 Antibody - H00011252-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: PACSIN2 Antibody [H00011252-B01] - analysis of PACSIN2 expression in transfected 293T cell line by PACSIN2 MaxPab polyclonal antibody (B01). Lane 1: PACSIN2 transfected lysate (55.70 KDa). Lane 2: Non-transfected lysate.

PACSIN2 Antibody - H00011252-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PACSIN2 Antibody [H00011252-D01P] - Analysis of PACSIN2 expression in transfected 293T cell line by PACSIN2 polyclonal antibody.Lane 1: PACSIN2 transfected lysate(55.70 KDa).Lane 2: Non-transfected lysate.

PACSIN2 Antibody - H00011252-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: PACSIN2 Antibody [H00011252-B01P] - Analysis of PACSIN2 expression in transfected 293T cell line by PACSIN2 polyclonal antibody. Lane 1: PACSIN2 transfected lysate(53.46 KDa). Lane 2: Non-transfected lysate.
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