PACSIN2

Gene Symbol	PACSIN2
Entrez Gene	11252
Alt Symbol	SDPII
Species	Human
Gene Type	protein-coding
Description	protein kinase C and casein kinase substrate in neurons 2
Other Description	cytoplasmic phosphoprotein PACSIN2|protein kinase C and casein kinase substrate in neurons protein 2|syndapin 2|syndapin II|syndapin-2|syndapin-II|syndapin2
Swissprots	Q9UNF0 Q9Y4V2 Q96HV9 O95921 Q9NPN1 Q9H0D3
Accessions	EAW73277 EAW73278 Q9UNF0 AF128536 AAD41781 AL136845 CAB66779 AL389984 CAB97538 AY007086 BC008037 AAH08037 BI964045 CR456536 CAG30422 CR533523 CAG38554 CU013136 CAK54567 CU013424 CAK54866 DQ892911 ABM83837 DQ896161 ABM87160 XM_005261319 XP_005261376 XM_011529846 XP_011528148 XM_011529847 XP_011528149 XM_011529848 XP_011528150 XM_011529849 XP_011528151 XM_011529850 XP_011528152 XM_011529851 XP_011528153 XM_011529852 XP_011528154 XM_011529853 XP_011528155 NM_001184970 NP_001171899 NM_001184971 NP_001171900 NM_007229 NP_009160
Function	Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000250}. Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PACSIN2 full length protein - ab153173 from Abcam Category Protein Source Wheat germ Species Human

Human PACSIN2 protein fragment - ab153174 from Abcam Category Protein Source Wheat germ Species Human

PACSIN2 Antibody Blocking Peptide - LS-E9485 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PACSIN2 Protein - H00011252-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PACSIN2 Protein - H00011252-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PACSIN2 Peptide - P3087 from Novus Biologicals Category Peptide Species Human

PACSIN2-Antibody-C-term-Blocking-Peptide - BP8088b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PACSIN2 - H00011252-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PACSIN2 - H00011252-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PACSIN2 - H00011252-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PACSIN2 - H00011252-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PACSIN2 fusion protein - Ag0809 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PACSIN2, His-tagged - PACSIN2-167H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human Protein kinase C and casein kinase substrate in neurons protei - CSB-YP890765HU CSB-EP890765HU CSB-BP890765HU CSB-MP890765HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PACSIN2 Protein - abx163931 from Abbexa Category Protein Species Human

PACSIN2 - TP300237 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Protein Kinase C, Substrate Peptide, Peptide - MBS659117 from MyBioSource Category Protein Prices $415.00 Sizes 1 mg Source Synthetic

PACSIN2 Recombinant Protein Antigen - NBP2-13723PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human PACSIN2 (C-His) protein - orb311964 from Biorbyt Category Protein Prices $366.00, $629.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

PACSIN2-Antibody-Center-Blocking-Peptide - BP8088c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PACSIN2 Peptide, Human - M34GP11235H from Creative Peptides Category Peptide Source Synthetic. Species Human

PACSIN2 Antibody - SH-A14278 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

PACSIN2 Recombinant Protein - 91-686 from ProSci Category Protein Prices $525.00 Sizes 50 µg Source Human Cells Species Human

PACSIN2 Recombinant Protein Antigen - NBP2-56701PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PACSIN2, Recombinant Protein - MBS8249540 from MyBioSource Category Protein Prices $255.00, $635.00, $2,370.00 Sizes 10 µg, 50 µg, 500 µg Source Human cells Species Human

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