PACSIN2

Gene Symbol PACSIN2
Entrez Gene 11252
Alt Symbol SDPII
Species Human
Gene Type protein-coding
Description protein kinase C and casein kinase substrate in neurons 2
Other Description cytoplasmic phosphoprotein PACSIN2|protein kinase C and casein kinase substrate in neurons protein 2|syndapin 2|syndapin II|syndapin-2|syndapin-II|syndapin2
Swissprots Q9UNF0 Q9Y4V2 Q96HV9 O95921 Q9NPN1 Q9H0D3
Accessions EAW73277 EAW73278 Q9UNF0 AF128536 AAD41781 AL136845 CAB66779 AL389984 CAB97538 AY007086 BC008037 AAH08037 BI964045 CR456536 CAG30422 CR533523 CAG38554 CU013136 CAK54567 CU013424 CAK54866 DQ892911 ABM83837 DQ896161 ABM87160 XM_005261319 XP_005261376 XM_011529846 XP_011528148 XM_011529847 XP_011528149 XM_011529848 XP_011528150 XM_011529849 XP_011528151 XM_011529850 XP_011528152 XM_011529851 XP_011528153 XM_011529852 XP_011528154 XM_011529853 XP_011528155 NM_001184970 NP_001171899 NM_001184971 NP_001171900 NM_007229 NP_009160
Function Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000250}. Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}.

PACSIN2 CRISPR/Cas9 KO Plasmid (h) - sc-417227 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 HDR Plasmid (h) - sc-417227-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 Double Nickase Plasmid (h) - sc-417227-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 Double Nickase Plasmid (h2) - sc-417227-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 CRISPR Activation Plasmid (h) - sc-417227-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 CRISPR Activation Plasmid (h2) - sc-417227-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 Lentiviral Activation Particles (h) - sc-417227-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 Lentiviral Activation Particles (h2) - sc-417227-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN2 siRNA (h) - sc-36173 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACSIN2 shRNA Plasmid (h) - sc-36173-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACSIN2 shRNA (h) Lentiviral Particles - sc-36173-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACSIN2 RNAi - H00011252-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU063441 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16262 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16262 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05177 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05177

PACSIN2 siRNA (Human) - CRH7713 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PACSIN2 shRNA Plasmid (Human) - CHH7713 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PACSIN2 miRNA 3'UTR clone - MiUTR3H-07247 from Creative biogene

Species Reactivities Human
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