| Gene Symbol |
PACSIN2
|
| Entrez Gene |
11252
|
| Alt Symbol |
SDPII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase C and casein kinase substrate in neurons 2
|
| Other Description |
cytoplasmic phosphoprotein PACSIN2|protein kinase C and casein kinase substrate in neurons protein 2|syndapin 2|syndapin II|syndapin-2|syndapin-II|syndapin2
|
| Swissprots |
Q9UNF0 Q9Y4V2 Q96HV9 O95921 Q9NPN1 Q9H0D3
|
| Accessions |
EAW73277 EAW73278 Q9UNF0 AF128536 AAD41781 AL136845 CAB66779 AL389984 CAB97538 AY007086 BC008037 AAH08037 BI964045 CR456536 CAG30422 CR533523 CAG38554 CU013136 CAK54567 CU013424 CAK54866 DQ892911 ABM83837 DQ896161 ABM87160 XM_005261319 XP_005261376 XM_011529846 XP_011528148 XM_011529847 XP_011528149 XM_011529848 XP_011528150 XM_011529849 XP_011528151 XM_011529850 XP_011528152 XM_011529851 XP_011528153 XM_011529852 XP_011528154 XM_011529853 XP_011528155 NM_001184970 NP_001171899 NM_001184971 NP_001171900 NM_007229 NP_009160
|
| Function |
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000250}. Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}.
|