Gene Symbol | KAT6A |
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Entrez Gene | 7994 |
Alt Symbol | MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220 |
Species | Human |
Gene Type | protein-coding |
Description | K(lysine) acetyltransferase 6A |
Other Description | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3|MYST histone acetyltransferase (monocytic leukemia) 3|histone acetyltransferase KAT6A|histone acetyltransferase MYST3|monocytic leukemia zinc finger protein|runt-related transcription factor binding protein 2|zinc finger protein 220 |
Swissprots | Q92794 |
Accessions | CCQ43374 EAW63239 EAW63240 Q92794 AA310750 AJ420560 AK128323 BC018011 BC142659 AAI42660 BC142959 AAI42960 BC172379 AAI72379 BP248857 BP271264 BP348860 CB216817 DA257528 DA442995 DA758316 U47742 AAC50662 XM_011544656 XP_011542958 XM_011544657 XP_011542959 XM_011544658 XP_011542960 XM_011544659 XP_011542961 XM_011544660 XP_011542962 NM_001305878 NP_001292807 NM_006766 NP_006757 NM_001099412 NP_001092882 NM_001099413 NP_001092883 |
Function | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
Subcellular Location | Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage. |
Top Pathways | Signaling pathways regulating pluripotency of stem cells |
MOZ (N-19) - sc-5713 from Santa Cruz Biotechnology
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MOZ (H-58) - sc-366555 from Santa Cruz Biotechnology
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MOZ (E-17) - sc-5715 from Santa Cruz Biotechnology
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MOZ (C-16) - sc-5716 from Santa Cruz Biotechnology
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Anti-Histone acetyltransferase MYST3 antibody - ab41718 from Abcam
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Anti-Histone acetyltransferase MYST3 antibody - ab110945 from Abcam
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Anti-Histone acetyltransferase MYST3 antibody - ab95454 from Abcam
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Anti-Histone acetyltransferase MYST3 antibody - C-terminal - ab170568 from Abcam
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Anti-MYST3 / MOZ Antibody - LS-C308977 from LifeSpan Bioscience
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Anti-MYST3 / MOZ Antibody (aa1319-1351) - LS-C164604 from LifeSpan Bioscience
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Anti-MYST3 / MOZ Antibody (clone 4D8) - LS-C133981 from LifeSpan Bioscience
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Anti-MYST3 / MOZ Antibody (C-Terminus) - LS-C48645 from LifeSpan Bioscience
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Anti-MYST3 / MOZ Antibody (aa1361-1372) IHC-plus⢠- LS-B4394 from LifeSpan Bioscience
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MYST3 Antibody - 21620002 from Novus Biologicals
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MYST3 Antibody (4D8) - H00007994-M07 from Novus Biologicals
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MYST3 Antibody - NBP1-44049 from Novus Biologicals
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Anti-MOZ/MYST3 (N-term) antibody produced in rabbit - SAB1300152 from Sigma-Aldrich
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Monoclonal Anti-MYST3 antibody produced in mouse - SAB1401412 from Sigma-Aldrich
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ANTI-MOZ/MYST3(C-TERMINAL) antibody produced in rabbit - SAB1305719 from Sigma-Aldrich
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MOZMYST3-Antibody-C-term - AP12197b from Abgent, a WuXi AppTec company
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MOZ--KAT6A-Antibody-Internal-region - AF2970a from Abgent, a WuXi AppTec company
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KAT6A antibody - GTX59754 from GeneTex
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MOZ / KAT6A antibody, Internal - GTX88406 from GeneTex
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MOZ/MYST3 Antibody - C-terminal region (OAAB08441) - OAAB08441 from Aviva Systems Biology
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Goat Anti-MOZ / KAT6A Antibody (OAEB00266) - OAEB00266 from Aviva Systems Biology
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