| Gene Symbol |
KAT6A
|
| Entrez Gene |
7994
|
| Alt Symbol |
MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
K(lysine) acetyltransferase 6A
|
| Other Description |
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3|MYST histone acetyltransferase (monocytic leukemia) 3|histone acetyltransferase KAT6A|histone acetyltransferase MYST3|monocytic leukemia zinc finger protein|runt-related transcription factor binding protein 2|zinc finger protein 220
|
| Swissprots |
Q92794
|
| Accessions |
CCQ43374 EAW63239 EAW63240 Q92794 AA310750 AJ420560 AK128323 BC018011 BC142659 AAI42660 BC142959 AAI42960 BC172379 AAI72379 BP248857 BP271264 BP348860 CB216817 DA257528 DA442995 DA758316 U47742 AAC50662 XM_011544656 XP_011542958 XM_011544657 XP_011542959 XM_011544658 XP_011542960 XM_011544659 XP_011542961 XM_011544660 XP_011542962 NM_001305878 NP_001292807 NM_006766 NP_006757 NM_001099412 NP_001092882 NM_001099413 NP_001092883
|
| Function |
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|