LCAT

Gene Symbol	LCAT
Entrez Gene	3931
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	lecithin-cholesterol acyltransferase
Other Description	phosphatidylcholine-sterol acyltransferase|phospholipid-cholesterol acyltransferase
Swissprots	Q53XQ3 P04180
Accessions	AAA59500 AAB20750 AAD28484 AAR03499 CAA28651 EAW83190 P04180 BC014781 AAH14781 BT009748 AAP88750 M12625 AAA59498 M26268 AAA59499 X06537 CAB56610 NM_000229 NP_000220
Function	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. {ECO:0000269|PubMed:10722751}.
Subcellular Location	Secreted {ECO:0000269|PubMed:19065001}. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
Tissue Specificity	Expressed mainly in brain, liver and testes. Secreted into plasma and cerebral spinal fluid. Expressed in Hep- G2 cell line. {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3797244}.
Top Pathways	Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LCAT (D-2) - sc-376682 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

LCAT (D-3) - sc-377509 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

LCAT (C-19) - sc-47899 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LCAT (K-15) - sc-47900 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LCAT (H-141) - sc-98874 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

LCAT (M-60) - sc-98873 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-LCAT antibody - ab103489 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-LCAT antibody [EPR1383(2)] - ab109417 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1383(2)

Anti-LCAT antibody [EPR1384Y] - ab51060 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1384Y

Anti-LCAT antibody [EPR1384Y] (HRP) - ab201345 from Abcam Prices $425.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1384Y

Anti-LCAT antibody - C-terminal - ab191148 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (C-Terminus) - LS-C8462 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa285-313, APC) - LS-C261747 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (N-Terminus) - LS-C31950 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa285-313, AP) - LS-C261748 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa285-313, Biotin) - LS-C261749 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa285-313, FITC) - LS-C261751 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa285-313, Azide-free, HRP) - LS-C261753 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa362-411) - LS-C80450 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa285-313, PE) - LS-C261754 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (Internal, clone EPR1383(2)) - LS-C138229 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1383(2)

Anti-LCAT Antibody - LS-C146694 from LifeSpan Bioscience Prices $325.00 Sizes 500 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (C-Terminus) - LS-C142502 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa41-210, Biotin) - LS-C298062 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LCAT Antibody (aa41-210, Biotin) - LS-C298063 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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