LCAT

Gene Symbol	LCAT
Entrez Gene	3931
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	lecithin-cholesterol acyltransferase
Other Description	phosphatidylcholine-sterol acyltransferase|phospholipid-cholesterol acyltransferase
Swissprots	Q53XQ3 P04180
Accessions	AAA59500 AAB20750 AAD28484 AAR03499 CAA28651 EAW83190 P04180 BC014781 AAH14781 BT009748 AAP88750 M12625 AAA59498 M26268 AAA59499 X06537 CAB56610 NM_000229 NP_000220
Function	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. {ECO:0000269|PubMed:10722751}.
Subcellular Location	Secreted {ECO:0000269|PubMed:19065001}. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
Tissue Specificity	Expressed mainly in brain, liver and testes. Secreted into plasma and cerebral spinal fluid. Expressed in Hep- G2 cell line. {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3797244}.
Top Pathways	Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat LCAT ELISA Kit (Sandwich ELISA) - LS-F6789 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 28.7 pg/ml Range 0.469-30 ng/ml

Human LCAT ELISA Kit (Sandwich ELISA) - LS-F6668 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.19 ng/ml Range 0.469-30 ng/ml

Mouse LCAT ELISA Kit (Sandwich ELISA) - LS-F7701 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.469-30 ng/ml

Human LCAT ELISA Kit - abx152176 from Abbexa Category ELISA Kit Sensitivity 0.19 ng/ml Range 0.469 ng/ml - 30 ng/ml

Lecithin Cholesterol Acyltransferase (LCAT), Human, ELISA Kit - CSB-E13469h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.78ng/ml Range 3.12 ng/ml-200 ng/ml

Lecithin Cholesterol Acyltransferase (LCAT), Human, ELISA Kit - SEJ516Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.19ng/mL Range 0.47-30ng/mL

Phosphatidylcholine-sterol acyltransferase (LCAT), Human, ELISA Kit - E01P0814 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Phosphatidylcholine-sterol acyltransferase, LCAT, Human, ELISA Kit - E2114h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Lecithin-Cholesterol Acyltransferase, LCAT, Rat, ELISA Kit - E-EL-R0553 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Lecithin Cholesterol Acyltransferase (LCAT), Human, CLIA Kit - SCJ516Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.87ng/mL Range 2.35-150ng/mL

Human LCAT ELISA Kit - HL0310 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human Lecithin-Cholesterol Acyltransferase ELISA Kit - DEIA4716 from Creative Diagnostics Category ELISA Kit Sensitivity Limit of detection (LOD) (defined as concentration of analyte giving absorbance higher than mean absorbance of blank* plus three standard deviations of the absorbance of blank: Ablank + 3xSDblank) is calculated from the real human LCAT values in wells and

Human LCAT(Lecithin-Cholesterol Acyltransferase) ELISA Kit - E-EL-H2456 from Elabscience Category ELISA Kit Sensitivity 0.94 ng/mL Range 1.56—100 ng/mL

LCAT, ELISA Kit - MBS2516010 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human LCAT is 0.938ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 1.563-100ng/mL

LCAT, ELISA Kit - MBS2508140 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625--40ng/mL

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS049413 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS011278 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS090664 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS018986 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS058667 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS088117 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS046910 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS107851 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS098894 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lecithin Cholesterol Acyltransferase, ELISA Kit - MBS009808 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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