LCAT

Gene Symbol	LCAT
Entrez Gene	3931
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	lecithin-cholesterol acyltransferase
Other Description	phosphatidylcholine-sterol acyltransferase|phospholipid-cholesterol acyltransferase
Swissprots	Q53XQ3 P04180
Accessions	AAA59500 AAB20750 AAD28484 AAR03499 CAA28651 EAW83190 P04180 BC014781 AAH14781 BT009748 AAP88750 M12625 AAA59498 M26268 AAA59499 X06537 CAB56610 NM_000229 NP_000220
Function	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. {ECO:0000269|PubMed:10722751}.
Subcellular Location	Secreted {ECO:0000269|PubMed:19065001}. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
Tissue Specificity	Expressed mainly in brain, liver and testes. Secreted into plasma and cerebral spinal fluid. Expressed in Hep- G2 cell line. {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3797244}.
Top Pathways	Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-LCAT-cDNA-Clone - DC03933 from Abgent, a WuXi AppTec company Prices $594.00 Sizes 10 µg Species Human Accession BC014781

LCAT - MBS1276287 from MyBioSource Species Human Accession BC014781

Human LCAT cDNA clone(NM_000229.1) - CDFH010239 from Creative Biomart Species Human Accession NM_000229.1

Human LCAT cDNA clone(NM_000229.1) - CDFH010240 from Creative Biomart

Human LCAT ORF Clone(NM_000229.1) - CDCR279235 from Creative Biomart Species Human Accession NM_000229.1

Human LCAT ORF Clone(NM_000229.1) - CDCR279236 from Creative Biomart Species Human Accession NM_000229.1

Human LCAT ORF Clone(NM_000229.1) - CDCR279237 from Creative Biomart Species Human Accession NM_000229.1

Human LCAT Gene ORF cDNA clone in cloning vector - HG13271-G from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, N-HA tag - HG13271-NY from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13271-NM from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, N-His tag - HG13271-NH from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13271-CF from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13271-CM from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13271-ACR from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, C-His tag - HG13271-CH from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13271-ACG from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid - HG13271-UT from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, C-HA tag - HG13271-CY from Sino Biological Species Human

Human LCAT Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13271-NF from Sino Biological Species Human

Mouse LCAT ORF clone (NM_000229.1) - CDCL126397 from Creative biogene Species Human

Human LCAT ORF Clone (BC014781) - CDCS405513 from Creative biogene Species Human Accession P04180

Human LCAT ORF clone (BC014781) - CDCB160063 from Creative biogene Species Human

Human lecithin-cholesterol acyltransferase Gene - orb144046 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human LCAT cDNA Clone(NM_000229.1) - CDFH010239 from Creative biogene Species Human

Human LCAT cDNA Clone(NM_000229.1) - CDFH010240 from Creative biogene Species Human

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