| Gene Symbol |
LCAT
|
| Entrez Gene |
3931
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lecithin-cholesterol acyltransferase
|
| Other Description |
phosphatidylcholine-sterol acyltransferase|phospholipid-cholesterol acyltransferase
|
| Swissprots |
Q53XQ3 P04180
|
| Accessions |
AAA59500 AAB20750 AAD28484 AAR03499 CAA28651 EAW83190 P04180 BC014781 AAH14781 BT009748 AAP88750 M12625 AAA59498 M26268 AAA59499 X06537 CAB56610 NM_000229 NP_000220
|
| Function |
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. {ECO:0000269|PubMed:10722751}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:19065001}. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
|
| Tissue Specificity |
Expressed mainly in brain, liver and testes. Secreted into plasma and cerebral spinal fluid. Expressed in Hep- G2 cell line. {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3797244}.
|
| Top Pathways |
Glycerophospholipid metabolism
|
