LCAT

Gene Symbol	LCAT
Entrez Gene	3931
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	lecithin-cholesterol acyltransferase
Other Description	phosphatidylcholine-sterol acyltransferase|phospholipid-cholesterol acyltransferase
Swissprots	Q53XQ3 P04180
Accessions	AAA59500 AAB20750 AAD28484 AAR03499 CAA28651 EAW83190 P04180 BC014781 AAH14781 BT009748 AAP88750 M12625 AAA59498 M26268 AAA59499 X06537 CAB56610 NM_000229 NP_000220
Function	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. {ECO:0000269|PubMed:10722751}.
Subcellular Location	Secreted {ECO:0000269|PubMed:19065001}. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
Tissue Specificity	Expressed mainly in brain, liver and testes. Secreted into plasma and cerebral spinal fluid. Expressed in Hep- G2 cell line. {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3797244}.
Top Pathways	Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LCAT full length protein - ab139631 from Abcam Category Protein Source E. coli Species Human

Human LCAT full length protein - ab104359 from Abcam Category Protein Source HEK 293 cells Species Human

Human LCAT peptide - ab85826 from Abcam Category Peptide

LCAT Antibody Blocking Peptide - LS-E10361 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LCAT Antibody Blocking Peptide - LS-E15342 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LCAT Partial Recombinant Protein - H00003931-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human LCAT Protein - H00003931-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LCAT-Antibody-Center-Blocking-Peptide - BP9868c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Phosphatidylcholine-sterol acyltransferase (OPCA00911) - OPCA00911 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Human

LCat Protein (OPPA01683) - OPPA01683 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

LCat Protein (OPPA02410) - OPPA02410 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Human Embryonic Kidney 293 cells

Human LCAT (His Tag) protein - orb232302 from Biorbyt Category Protein Prices $281.00, $527.00 Sizes 20 μg, 100 μg Species Human

Human LCAT protein - orb245499 from Biorbyt Category Protein Prices $213.00, $374.00, $638.00, $859.00, $1,275.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human LCAT, HEK protein - orb90164 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source Human Embryonic Kidney 293 cells Species Human

Human LCAT protein - orb90163 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

LCAT Blocking Peptide - 33R-3643 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LCAT Blocking Peptide - 33R-6057 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LCAT protein (His tag) - 30R-2963 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human LCAT Protein - abx067721 from Abbexa Category Protein Source E.coli Species Human

LCAT (25-440, His-tag) - AR50723PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

LCAT (25-440, His-tag) - AR50723PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

LCAT - H00003931-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LCAT - H00003931-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LCAT - H00003931-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LCAT - H00003931-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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