FGD5

Gene Symbol FGD5
Entrez Gene 152273
Alt Symbol ZFYVE23
Species Human
Gene Type protein-coding
Description FYVE, RhoGEF and PH domain containing 5
Other Description FYVE, RhoGEF and PH domain-containing protein 5|zinc finger FYVE domain-containing protein 23
Swissprots Q8IYP3 Q6ZNL6 B3KVQ3 Q6MZY1 Q8N8G4 Q8N861 Q7Z303
Accessions CCO13730 EAW64208 EAW64209 Q6ZNL6 AK057128 AK096856 BAC04878 AK097276 BAC04989 AK123054 BAG53865 AK131078 BAC85128 BC035364 AAH35364 BC040614 BC132814 AAI32815 BC132816 AAI32817 BC144300 AAI44301 BX538312 CAD98090 BX640820 CAE45896 JF432210 ADZ15427 XM_011533422 XP_011531724 XM_011533423 XP_011531725 XM_011533424 XP_011531726 NM_152536 NP_689749
Function Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22328776}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22328776}. Endoplasmic reticulum {ECO:0000269|PubMed:22328776}. Golgi apparatus {ECO:0000269|PubMed:22328776}. Early endosome {ECO:0000269|PubMed:22328776}. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
Tissue Specificity Expressed in endothelial cells (at protein level). {ECO:0000269|PubMed:22328776}.

FGD5 293T Cell Transient Overexpression Lysate(Denatured) - H00152273-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

FGD5 overexpression lysate - LY432449 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

FGD5 Overexpression Lysate (Denatured) - H00152273-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
FGD5 transfected lysate.

FGD5 Overexpression Lysate (Native) - NBP2-10241 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: FGD5 Overexpression Lysate (Adult Normal) [NBP2-10241] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FGD5.

Panoply™ Human FGD5 Knockdown Stable Cell Line - CSC-DC005691 from Creative biogene

Category Cell Line
Species Human
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