| Gene Symbol |
FGD5
|
| Entrez Gene |
152273
|
| Alt Symbol |
ZFYVE23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FYVE, RhoGEF and PH domain containing 5
|
| Other Description |
FYVE, RhoGEF and PH domain-containing protein 5|zinc finger FYVE domain-containing protein 23
|
| Swissprots |
Q8IYP3 Q6ZNL6 B3KVQ3 Q6MZY1 Q8N8G4 Q8N861 Q7Z303
|
| Accessions |
CCO13730 EAW64208 EAW64209 Q6ZNL6 AK057128 AK096856 BAC04878 AK097276 BAC04989 AK123054 BAG53865 AK131078 BAC85128 BC035364 AAH35364 BC040614 BC132814 AAI32815 BC132816 AAI32817 BC144300 AAI44301 BX538312 CAD98090 BX640820 CAE45896 JF432210 ADZ15427 XM_011533422 XP_011531724 XM_011533423 XP_011531725 XM_011533424 XP_011531726 NM_152536 NP_689749
|
| Function |
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22328776}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22328776}. Endoplasmic reticulum {ECO:0000269|PubMed:22328776}. Golgi apparatus {ECO:0000269|PubMed:22328776}. Early endosome {ECO:0000269|PubMed:22328776}. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
|
| Tissue Specificity |
Expressed in endothelial cells (at protein level). {ECO:0000269|PubMed:22328776}.
|