FGD5

Gene Symbol	FGD5
Entrez Gene	152273
Alt Symbol	ZFYVE23
Species	Human
Gene Type	protein-coding
Description	FYVE, RhoGEF and PH domain containing 5
Other Description	FYVE, RhoGEF and PH domain-containing protein 5|zinc finger FYVE domain-containing protein 23
Swissprots	Q8IYP3 Q6ZNL6 B3KVQ3 Q6MZY1 Q8N8G4 Q8N861 Q7Z303
Accessions	CCO13730 EAW64208 EAW64209 Q6ZNL6 AK057128 AK096856 BAC04878 AK097276 BAC04989 AK123054 BAG53865 AK131078 BAC85128 BC035364 AAH35364 BC040614 BC132814 AAI32815 BC132816 AAI32817 BC144300 AAI44301 BX538312 CAD98090 BX640820 CAE45896 JF432210 ADZ15427 XM_011533422 XP_011531724 XM_011533423 XP_011531725 XM_011533424 XP_011531726 NM_152536 NP_689749
Function	Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22328776}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22328776}. Endoplasmic reticulum {ECO:0000269|PubMed:22328776}. Golgi apparatus {ECO:0000269|PubMed:22328776}. Early endosome {ECO:0000269|PubMed:22328776}. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
Tissue Specificity	Expressed in endothelial cells (at protein level). {ECO:0000269|PubMed:22328776}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FGD5 full length protein - ab165644 from Abcam Category Protein Source Wheat germ Species Human

FGD5 Antibody Blocking Peptide - LS-E25012 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FGD5 Protein - H00152273-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FGD5 - H00152273-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FGD5 - H00152273-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FGD5 fusion protein - Ag15446 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

FGD5 fusion protein - Ag15037 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human FGD5, His-tagged - FGD5-12860H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5(FGD5) ,partial - CSB-YP757939HU CSB-EP757939HU CSB-BP757939HU CSB-MP757939HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FGD5 Protein - abx163059 from Abbexa Category Protein Species Human

FGD5 Recombinant Protein Antigen - NBP1-83878PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FGD5 Recombinant Protein Antigen - NBP1-83877PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FGD5 Peptide, Human - M34GP05691H from Creative Peptides Category Peptide Source Synthetic. Species Human

FYVE, RhoGEF and PH domain-containing protein 5 (FGD5), partial, Recombinant Protein - MBS1393507 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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