FGD5

Gene Symbol FGD5
Entrez Gene 152273
Alt Symbol ZFYVE23
Species Human
Gene Type protein-coding
Description FYVE, RhoGEF and PH domain containing 5
Other Description FYVE, RhoGEF and PH domain-containing protein 5|zinc finger FYVE domain-containing protein 23
Swissprots Q8IYP3 Q6ZNL6 B3KVQ3 Q6MZY1 Q8N8G4 Q8N861 Q7Z303
Accessions CCO13730 EAW64208 EAW64209 Q6ZNL6 AK057128 AK096856 BAC04878 AK097276 BAC04989 AK123054 BAG53865 AK131078 BAC85128 BC035364 AAH35364 BC040614 BC132814 AAI32815 BC132816 AAI32817 BC144300 AAI44301 BX538312 CAD98090 BX640820 CAE45896 JF432210 ADZ15427 XM_011533422 XP_011531724 XM_011533423 XP_011531725 XM_011533424 XP_011531726 NM_152536 NP_689749
Function Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22328776}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22328776}. Endoplasmic reticulum {ECO:0000269|PubMed:22328776}. Golgi apparatus {ECO:0000269|PubMed:22328776}. Early endosome {ECO:0000269|PubMed:22328776}. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
Tissue Specificity Expressed in endothelial cells (at protein level). {ECO:0000269|PubMed:22328776}.

FGD5 CRISPR/Cas9 KO Plasmid (h) - sc-414717 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 HDR Plasmid (h) - sc-414717-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 Double Nickase Plasmid (h) - sc-414717-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 Double Nickase Plasmid (h2) - sc-414717-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 CRISPR Activation Plasmid (h) - sc-414717-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 CRISPR Activation Plasmid (h2) - sc-414717-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 Lentiviral Activation Particles (h) - sc-414717-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 Lentiviral Activation Particles (h2) - sc-414717-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGD5 siRNA (h) - sc-78172 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FGD5 shRNA Plasmid (h) - sc-78172-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FGD5 shRNA (h) Lentiviral Particles - sc-78172-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU033481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8643 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8643 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08857 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08857

FGD5 siRNA (Human) - CRJ5736 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FGD5 RNAi - H00152273-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FGD5 - MBS8202698 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FGD5 (NM_152536.3) - SHH294337 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FGD5(NM_152536.3) - SHH056675 from Creative biogene

Category siRNA
Species Reactivities Human

Human FGD5 siRNA - orb276237 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FGD5 shRNA Plasmid (Human) - CHJ5736 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FGD5 miRNA 3'UTR clone - MiUTR1H-03622 from Creative biogene

Species Reactivities Human
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