DAPK3

Gene Symbol DAPK3
Entrez Gene 1613
Alt Symbol DLK, ZIP, ZIPK
Species Human
Gene Type protein-coding
Description death-associated protein kinase 3
Other Description DAP kinase 3|DAP-like kinase|MYPT1 kinase|ZIP-kinase|zipper-interacting protein kinase
Swissprots B3KQE2 Q05JY4 O43293 A0AVN4
Accessions CAF85967 EAW69276 O43293 AB007144 BAA24955 AB022341 BAA81746 AB265224 BAF34614 AI654829 AK027590 BAG51355 AK074799 BAG52004 AK093792 BAG52765 AK097643 BC126430 AAI26431 BC126432 AAI26433 DA748997 HQ258253 ADR83007 HY104892 XM_005259508 XP_005259565 NM_001348 NP_001339
Function Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase- dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers i
Subcellular Location Isoform 2: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.
Tissue Specificity Widely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle. {ECO:0000269|PubMed:15292222, ECO:0000269|PubMed:17126281}.
Top Pathways Bladder cancer

DAPK3/ZIPK Antibody - 2928 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using DAPK3/ZIPK Antibody.

ZIP-kinase (C-3) - sc-514223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ZIP-kinase (C-3): sc-514223. Western blot analysis of ZIP-kinase expression in Hep G2 (A), HeLa (B) and Jurkat (C) whole cell lysates.

ZIP-kinase (G-1) - sc-514331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ZIP-kinase (G-1): sc-514331. Western blot analysis of ZIP-kinase expression in non-transfected 293T: sc-117752 (A), human ZIP-kinase transfected 293T: sc-373091 (B) and HUV-EC-C (C) whole cell lysates.

ZIP-kinase (17) - sc-136398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ZIP-kinase (17): sc-136398. Western blot analysis of ZIP-kinase expression in Hep G2 whole cell lysate.

ZIP-kinase (C-19) - sc-8161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ZIP-kinase (N-19) - sc-8162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ZIP-kinase (N-19): sc-8162. Western blot analysis of ZIP-kinase expression in non-transfected: sc-117752 (A) and human ZIP-kinase transfected: sc-373091 (B) 293T whole cell lysates.

Anti-ZIP Kinase (phospho T265) antibody - ab63395 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cells, using ab63395 at a 1:500.Left image untreated.Right image treated with phospho peptide.

Anti-ZIP Kinase antibody - ab2057 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ZIP Kinase antibody (ab2057) at 1/500 dilutionLane 1 : HeLa whole cell lysateLane 2 : Jurkat whole cell lysateObserved band size : 40 kDa (why is the actual band size different from the predicted?)

Anti-ZIP Kinase antibody - ab151956 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ZIP Kinase antibody (ab151956) at 1/500 dilution + A549 whole cell lysate at 30 µg

Anti-ZIP Kinase antibody - ab199647 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ZIP Kinase antibody (ab199647) at 1/1000 dilutionLane 1 : Hela whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-ZIP Kinase antibody - ab115695 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry Image of Human Small Intestine, Peyer's Patch (formalin-fixed, paraffin-embedded) stained with ZIP kinase antibody (ab115695) at 2.5 &microg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-ZIP Kinase antibody - ab78943 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ab78943 at 1/50 dilution in the absence or presence of immunising peptide.

Anti-ZIP Kinase antibody [EPR1635] - ab79422 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1635
All lanes : Anti-ZIP Kinase antibody [EPR1635] (ab79422) at 1/5000 dilutionLane 1 : HeLa cell lysateLane 2 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ZIP Kinase antibody [EPR1636Y] - ab51602 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1636Y
Anti-ZIP Kinase antibody [EPR1636Y] (ab51602) at 1/1000 dilution + HeLa cell lysate at 10 µgSecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-DAPK3 / ZIP Kinase Antibody - LS-C26619 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of anti-ZIPK antibody on HeLa (1) and Jurkat (2) whole cell lysates

Anti-DAPK3 / ZIP Kinase Antibody (C-Terminus, clone EPR1636Y) - LS-C49987 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1636Y
Western blot analysis on HeLa cell lysate using anti-DAPK3 antibody, dilution 1:1000.

Anti-DAPK3 / ZIP Kinase Antibody (N-Terminus, clone EPR1635) - LS-C105519 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1635
Western blot analysis on (A) HeLa and (B) A431 cell lysates using anti- DAPK3 antibody (LS-C105519), dilution: 1:5000.

Anti-DAPK3 / ZIP Kinase Antibody - LS-C153211 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DAPK3 / ZIP Kinase Antibody (aa241-290) - LS-C117877 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma tissue, using DAPK3 (Ab-265) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-DAPK3 / ZIP Kinase Antibody (aa254-282, AP) - LS-C255849 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK3 / ZIP Kinase Antibody (aa254-282, APC) - LS-C255852 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK3 / ZIP Kinase Antibody (aa254-282, Biotin) - LS-C259159 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK3 / ZIP Kinase Antibody (aa254-282, FITC) - LS-C259160 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK3 / ZIP Kinase Antibody (aa254-282, Azide-free, HRP) - LS-C259161 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK3 / ZIP Kinase Antibody (aa254-282, PE) - LS-C259163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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