DAPK3
| Gene Symbol | DAPK3 |
|---|---|
| Entrez Gene | 1613 |
| Alt Symbol | DLK, ZIP, ZIPK |
| Species | Human |
| Gene Type | protein-coding |
| Description | death-associated protein kinase 3 |
| Other Description | DAP kinase 3|DAP-like kinase|MYPT1 kinase|ZIP-kinase|zipper-interacting protein kinase |
| Swissprots | B3KQE2 Q05JY4 O43293 A0AVN4 |
| Accessions | CAF85967 EAW69276 O43293 AB007144 BAA24955 AB022341 BAA81746 AB265224 BAF34614 AI654829 AK027590 BAG51355 AK074799 BAG52004 AK093792 BAG52765 AK097643 BC126430 AAI26431 BC126432 AAI26433 DA748997 HQ258253 ADR83007 HY104892 XM_005259508 XP_005259565 NM_001348 NP_001339 |
| Function | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase- dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers i |
| Subcellular Location | Isoform 2: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}. |
| Tissue Specificity | Widely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle. {ECO:0000269|PubMed:15292222, ECO:0000269|PubMed:17126281}. |
| Top Pathways | Bladder cancer |
ZIP-kinase CRISPR/Cas9 KO Plasmid (h) - sc-409173 from Santa Cruz Biotechnology
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ZIP-kinase HDR Plasmid (h) - sc-409173-HDR from Santa Cruz Biotechnology
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ZIP-kinase Double Nickase Plasmid (h) - sc-409173-NIC from Santa Cruz Biotechnology
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ZIP-kinase Double Nickase Plasmid (h2) - sc-409173-NIC-2 from Santa Cruz Biotechnology
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ZIP-kinase CRISPR Activation Plasmid (h) - sc-409173-ACT from Santa Cruz Biotechnology
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ZIP-kinase CRISPR Activation Plasmid (h2) - sc-409173-ACT-2 from Santa Cruz Biotechnology
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ZIP-kinase Lentiviral Activation Particles (h) - sc-409173-LAC from Santa Cruz Biotechnology
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ZIP-kinase Lentiviral Activation Particles (h2) - sc-409173-LAC-2 from Santa Cruz Biotechnology
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ZIP-kinase siRNA (h) - sc-38983 from Santa Cruz Biotechnology
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ZIP-kinases shRNA Plasmid (h) - sc-38983-SH from Santa Cruz Biotechnology
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ZIP-kinases shRNA (h) Lentiviral Particles - sc-38983-V from Santa Cruz Biotechnology
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DAPK3/ZIPK RNAi - H00001613-R02 from Novus Biologicals
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MISSION® esiRNA - EHU119911 from Sigma-Aldrich
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MISSION® siRNA - SIHK0545 from Sigma-Aldrich
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MISSION® siRNA - SIHK0546 from Sigma-Aldrich
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MISSION® siRNA - SIHK0544 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6929 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6929 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06147 from Sigma-Aldrich
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DAPK3 siRNA (Human) - CRH1136 from Cohesion Biosciences
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DAPK3 - MBS8235572 from MyBioSource
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shRNA set against Human Dapk3 (NM_001348.1) - SHH274557 from Creative biogene
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shRNA set against Human DAPK3(NM_001348.1) - SHG221707 from Creative biogene
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Human DAPK3 siRNA - orb261638 from Biorbyt
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DAPK3 shRNA Plasmid (Human) - CHH1136 from Cohesion Biosciences
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