DAPK3

Gene Symbol	DAPK3
Entrez Gene	1613
Alt Symbol	DLK, ZIP, ZIPK
Species	Human
Gene Type	protein-coding
Description	death-associated protein kinase 3
Other Description	DAP kinase 3|DAP-like kinase|MYPT1 kinase|ZIP-kinase|zipper-interacting protein kinase
Swissprots	B3KQE2 Q05JY4 O43293 A0AVN4
Accessions	CAF85967 EAW69276 O43293 AB007144 BAA24955 AB022341 BAA81746 AB265224 BAF34614 AI654829 AK027590 BAG51355 AK074799 BAG52004 AK093792 BAG52765 AK097643 BC126430 AAI26431 BC126432 AAI26433 DA748997 HQ258253 ADR83007 HY104892 XM_005259508 XP_005259565 NM_001348 NP_001339
Function	Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase- dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers i
Subcellular Location	Isoform 2: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.
Tissue Specificity	Widely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle. {ECO:0000269|PubMed:15292222, ECO:0000269|PubMed:17126281}.
Top Pathways	Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ZIP Kinase full length protein - ab63192 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human ZIP Kinase full length protein - ab152327 from Abcam Category Protein Source Wheat germ Species Human

Human ZIP Kinase protein fragment - ab152328 from Abcam Category Protein Source Wheat germ Species Human

ZIP Kinase peptide - ab8383 from Abcam Category Peptide

DAPK3 / ZIP Kinase Antibody Blocking Peptide - LS-E3518 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAPK3 / ZIP Kinase Antibody Blocking Peptide - LS-E29877 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human DAPK3/ZIPK Protein - H00001613-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DAPK3/ZIPK Partial Recombinant Protein - H00001613-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DAPK3/ZIPK Blocking Peptide - NBP1-76962PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

DAP Kinase 3 peptide - GTX28383 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human DAP kinase 3 protein - orb84166 from Biorbyt Category Protein Prices $570.00, $663.00 Sizes 20 μg, 50 μg Source Insect Species Human

DAPK3 / ZIPK - H00001613-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DAPK3 / ZIPK - H00001613-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DAPK3 / ZIPK - H00001613-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DAPK3 / ZIPK - H00001613-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DAPK3 / ZIPK - P5531 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

DAPK3 / ZIPK Control Peptide - AP31006CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ZIPK Peptide - 2067P from ProSci Category Peptide Species Human

Recombinant Human DAPK3 - DAPK3-30752TH from Creative Biomart Category Protein Species Human

Recombinant Human DAPK3, 1-659, GST-tagged, Active - DAPK3-292H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus .

Recombinant Human DAPK3, GST-tagged, Active - DAPK3-291H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human Death-Associated Protein Kinase 3, GST-tagged - DAPK3-949H from Creative Biomart Category Protein Source Human

Recombinant Human Death-Associated Protein Kinase 3, GST-tagged - DAPK3-892H from Creative Biomart Category Protein Source Human

DAPK3 - PN201480 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Baculovirus-Insect cells Species Human

Recombinant Death Associated Protein Kinase 3 (DAPK3) - RPF163Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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