DAPK3

Gene Symbol	DAPK3
Entrez Gene	1613
Alt Symbol	DLK, ZIP, ZIPK
Species	Human
Gene Type	protein-coding
Description	death-associated protein kinase 3
Other Description	DAP kinase 3|DAP-like kinase|MYPT1 kinase|ZIP-kinase|zipper-interacting protein kinase
Swissprots	B3KQE2 Q05JY4 O43293 A0AVN4
Accessions	CAF85967 EAW69276 O43293 AB007144 BAA24955 AB022341 BAA81746 AB265224 BAF34614 AI654829 AK027590 BAG51355 AK074799 BAG52004 AK093792 BAG52765 AK097643 BC126430 AAI26431 BC126432 AAI26433 DA748997 HQ258253 ADR83007 HY104892 XM_005259508 XP_005259565 NM_001348 NP_001339
Function	Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase- dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers i
Subcellular Location	Isoform 2: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.
Tissue Specificity	Widely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle. {ECO:0000269|PubMed:15292222, ECO:0000269|PubMed:17126281}.
Top Pathways	Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DAPK3 - MBS1271387 from MyBioSource Species Human Accession BC126430

Human DAPK3 cDNA clone(NM_001348.1) - CDFH004753 from Creative Biomart Species Human Accession NM_001348.1

Human DAPK3 cDNA clone(NM_001348.1) - CDFH004754 from Creative Biomart Species Human Accession NM_001348.1

Human DAPK3 ORF clone(NM_001348.1) - CDCL183888 from Creative Biomart Species Human Accession NM_001348.1

Human DAPK3 ORF Clone(NM_001348.1) - CDCR280586 from Creative Biomart Species Human Accession NM_001348.1

Human DAPK3 ORF Clone(NM_001348.1) - CDCR280587 from Creative Biomart Species Human Accession NM_001348.1

Human DAPK3/ZIPK Gene ORF cDNA clone in cloning vector - HG10757-M from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10757-NM from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10757-M-F from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10757-CF from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10757-ACG from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, C-HA tag - HG10757-CY from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, N-His tag - HG10757-NH from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10757-ANG from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10757-CM from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, N-HA tag - HG10757-NY from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, C-His tag - HG10757-CH from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10757-ACR from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10757-ANR from Sino Biological Species Human

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid - HG10757-UT from Sino Biological Species Human

Human DAPK3 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10757-M-N from Sino Biological Species Human Accession NM_001348.1

Human DAPK3/ZIPK Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10757-NF from Sino Biological Species Human

Human DAPK3 ORF clone(NM_001348.1) - CDCL183888 from Creative biogene Species Human

Human DAPK3 ORF Clone (BC126430) - CDCS410241 from Creative biogene Species Human Accession O43293

Human DAPK3 cDNA Clone(NM_001348.1) - CDFH004753 from Creative biogene Species Human

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