DAPK3

Gene Symbol	DAPK3
Entrez Gene	1613
Alt Symbol	DLK, ZIP, ZIPK
Species	Human
Gene Type	protein-coding
Description	death-associated protein kinase 3
Other Description	DAP kinase 3|DAP-like kinase|MYPT1 kinase|ZIP-kinase|zipper-interacting protein kinase
Swissprots	B3KQE2 Q05JY4 O43293 A0AVN4
Accessions	CAF85967 EAW69276 O43293 AB007144 BAA24955 AB022341 BAA81746 AB265224 BAF34614 AI654829 AK027590 BAG51355 AK074799 BAG52004 AK093792 BAG52765 AK097643 BC126430 AAI26431 BC126432 AAI26433 DA748997 HQ258253 ADR83007 HY104892 XM_005259508 XP_005259565 NM_001348 NP_001339
Function	Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase- dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers i
Subcellular Location	Isoform 2: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.
Tissue Specificity	Widely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle. {ECO:0000269|PubMed:15292222, ECO:0000269|PubMed:17126281}.
Top Pathways	Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-DAPK3 / ZIP Kinase (Thr265) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1350 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat DAPK3 / ZIP Kinase ELISA Kit (Cell-Based ELISA) - LS-F1935 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse DAPK3 / ZIP Kinase ELISA Kit (Sandwich ELISA) - LS-F8129 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.156-10 ng/ml

DAPK3 Colorimetric Cell-Based ELISA Kit - CB5197 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

DAPK3 (Phospho-Thr265) Colorimetric Cell-Based ELISA Kit - CBP1360 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Death Associated Protein Kinase 3 (DAPK3), ELISA Kit - MBS2020740 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.058ng/mL. Range 0.156-10ng/mL

ELISA Kit for Death Associated Protein Kinase 3 (DAPK3) - SEF163Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

DAPK3 ELISA Kit - DEIA-XYA527 from Creative Diagnostics Category ELISA Kit

DAPK3 (Phospho-Thr265) ELISA Kit - DEIA-XYA528 from Creative Diagnostics Category ELISA Kit

Custom Human DAPK3/ZIPK ELISA - ELH-DAPK3-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human ZIPK ELISA Kit - orb384537 from Biorbyt Category ELISA Kit Prices $1,411.00, $2,448.00, $5,321.00 Sizes 96 assays, 192 assays, 480 assays

Human DAPK3 ELISA Kit - E011437 from Biobool Category ELISA Kit

Death Associated Protein Kinase 3 (DAPK3), ELISA Kit - MBS9375712 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DAPK3 Colorimetric Cell-Based ELISA Kit - EKA50170 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

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