| Gene Symbol | MCTS1 |
|---|---|
| Entrez Gene | 28985 |
| Alt Symbol | MCT-1, MCT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | malignant T cell amplified sequence 1 |
| Other Description | malignant T-cell-amplified sequence 1|multiple copies T-cell malignancies |
| Swissprots | Q502X6 B4DGY2 Q9ULC4 |
| Accessions | EAX11874 EAX11875 Q9ULC4 AA375691 AB034206 BAA86055 AF456465 AAM50513 AK096956 AK294834 BAG57943 AK311993 BAG34931 AW957695 AY364258 AAQ76817 BC001013 AAH01013 BC095461 AAH95461 BM671542 BP226595 HQ448721 ADQ33199 XR_938549 NM_001137554 NP_001131026 NM_014060 NP_054779 |
| Function | Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosph |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:16982740}. Note=Nuclear relocalization after DNA damage. |
| Tissue Specificity | Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. {ECO:0000269|PubMed:9766643}. |
Human MCTS1 ELISA Kit (Sandwich ELISA) - LS-F12017 from LifeSpan Bioscience
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Malignant T cell-amplified sequence 1, MCTS1, Human, ELISA Kit - E15021h from ARP American Research Products
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Malignant T cell-amplified sequence 1 (MCTS1), ELISA Kit - MBS9335741 from MyBioSource
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Rat MCTS1 ELISA Kit (Custom ELISA) - LS-F17651 from LifeSpan Bioscience
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Mouse MCTS1 ELISA Kit (Custom ELISA) - LS-F17652 from LifeSpan Bioscience
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Bovine MCTS1 ELISA Kit (Custom ELISA) - LS-F17653 from LifeSpan Bioscience
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Chicken MCTS1 ELISA Kit (Custom ELISA) - LS-F17654 from LifeSpan Bioscience
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MCTS1 - EKH3440 from Nordic BioSite
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MCTS1 ELISA Kit (Human) (OKEH02442) - OKEH02442 from Aviva Systems Biology
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Human MCTS1 ELISA Kit - E023543 from Biobool
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Human Malignant T cell-amplified sequence 1 ELISA Kit - EK3574 from Signalway Antibody
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Human Malignant T cell-amplified sequence 1 (MCTS1) ELISA Kit - AE33978HU from ARP American Research Products
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Malignant T cell-amplified sequence 1, ELISA Kit - MBS2882467 from MyBioSource
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Malignant T cell-amplified sequence 1, ELISA Kit - MBS9427408 from MyBioSource
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Human MCTS1 ELISA Kit (Sandwich ELISA) - LS-F35919 from LifeSpan Bioscience
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