MCTS1
| Gene Symbol | MCTS1 |
|---|---|
| Entrez Gene | 28985 |
| Alt Symbol | MCT-1, MCT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | malignant T cell amplified sequence 1 |
| Other Description | malignant T-cell-amplified sequence 1|multiple copies T-cell malignancies |
| Swissprots | Q502X6 B4DGY2 Q9ULC4 |
| Accessions | EAX11874 EAX11875 Q9ULC4 AA375691 AB034206 BAA86055 AF456465 AAM50513 AK096956 AK294834 BAG57943 AK311993 BAG34931 AW957695 AY364258 AAQ76817 BC001013 AAH01013 BC095461 AAH95461 BM671542 BP226595 HQ448721 ADQ33199 XR_938549 NM_001137554 NP_001131026 NM_014060 NP_054779 |
| Function | Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosph |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:16982740}. Note=Nuclear relocalization after DNA damage. |
| Tissue Specificity | Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. {ECO:0000269|PubMed:9766643}. |
MCTS1 CRISPR/Cas9 KO Plasmid (h) - sc-417359 from Santa Cruz Biotechnology
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MCTS1 HDR Plasmid (h) - sc-417359-HDR from Santa Cruz Biotechnology
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MCTS1 Double Nickase Plasmid (h) - sc-417359-NIC from Santa Cruz Biotechnology
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MCTS1 Double Nickase Plasmid (h2) - sc-417359-NIC-2 from Santa Cruz Biotechnology
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MCTS1 CRISPR Activation Plasmid (h) - sc-417359-ACT from Santa Cruz Biotechnology
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MCTS1 CRISPR Activation Plasmid (h2) - sc-417359-ACT-2 from Santa Cruz Biotechnology
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MCTS1 Lentiviral Activation Particles (h) - sc-417359-LAC from Santa Cruz Biotechnology
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MCTS1 Lentiviral Activation Particles (h2) - sc-417359-LAC-2 from Santa Cruz Biotechnology
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MCTS1 siRNA (h) - sc-91081 from Santa Cruz Biotechnology
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MCTS1 shRNA Plasmid (h) - sc-91081-SH from Santa Cruz Biotechnology
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MCTS1 shRNA (h) Lentiviral Particles - sc-91081-V from Santa Cruz Biotechnology
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MCTS1 RNAi - H00028985-R01 from Novus Biologicals
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MISSION® esiRNA - EHU108281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13134 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13134 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00249 from Sigma-Aldrich
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MCTS1 siRNA (Human) - CRH9148 from Cohesion Biosciences
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shRNA set against Human MCTS1 (NM_014060.2) - SHH339535 from Creative biogene
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Human MCTS1 siRNA - orb269650 from Biorbyt
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MCTS1 shRNA Plasmid (Human) - CHH9148 from Cohesion Biosciences
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MCTS1 miRNA 3'UTR clone - MiUTR4H-TG05423 from Creative biogene
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