| Gene Symbol |
MCTS1
|
| Entrez Gene |
28985
|
| Alt Symbol |
MCT-1, MCT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
malignant T cell amplified sequence 1
|
| Other Description |
malignant T-cell-amplified sequence 1|multiple copies T-cell malignancies
|
| Swissprots |
Q502X6 B4DGY2 Q9ULC4
|
| Accessions |
EAX11874 EAX11875 Q9ULC4 AA375691 AB034206 BAA86055 AF456465 AAM50513 AK096956 AK294834 BAG57943 AK311993 BAG34931 AW957695 AY364258 AAQ76817 BC001013 AAH01013 BC095461 AAH95461 BM671542 BP226595 HQ448721 ADQ33199 XR_938549 NM_001137554 NP_001131026 NM_014060 NP_054779
|
| Function |
Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosph
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:16982740}. Note=Nuclear relocalization after DNA damage.
|
| Tissue Specificity |
Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. {ECO:0000269|PubMed:9766643}.
|