MCTS1

Gene Symbol	MCTS1
Entrez Gene	28985
Alt Symbol	MCT-1, MCT1
Species	Human
Gene Type	protein-coding
Description	malignant T cell amplified sequence 1
Other Description	malignant T-cell-amplified sequence 1|multiple copies T-cell malignancies
Swissprots	Q502X6 B4DGY2 Q9ULC4
Accessions	EAX11874 EAX11875 Q9ULC4 AA375691 AB034206 BAA86055 AF456465 AAM50513 AK096956 AK294834 BAG57943 AK311993 BAG34931 AW957695 AY364258 AAQ76817 BC001013 AAH01013 BC095461 AAH95461 BM671542 BP226595 HQ448721 ADQ33199 XR_938549 NM_001137554 NP_001131026 NM_014060 NP_054779
Function	Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosph
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:16982740}. Note=Nuclear relocalization after DNA damage.
Tissue Specificity	Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. {ECO:0000269|PubMed:9766643}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Malignant T cell amplified sequence 1 full length protein - ab140541 from Abcam Category Protein Source E. coli Species Human

Recombinant Human MCTS1 Protein - H00028985-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MCTS1 Protein - NBP2-23214 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

MCT-1-Antibody-N-term-Blocking-Peptide - BP6655a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MCTS1 protein - orb246658 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

MCTS1 Blocking Peptide - 33R-5995 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MCTS1 protein (His tag) - 80R-2699 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Malignant T cell amplified sequence 1 Peptide - AC21-2755-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MCTS1 (1-181, His-tag) - AR50819PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

MCTS1 (1-181, His-tag) - AR50819PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

MCTS1 - H00028985-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MCTS1 - H00028985-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MCTS1, 1-181aa, Human, His tag, E.coli - 01-P1995 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

MCTS1 fusion protein - Ag6968 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MCTS1 fusion protein - Ag7057 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MCTS1 Human - PRPS-1394 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human MCTS1, His-tagged - MCTS1-7551H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MCTS1, GST-tagged - MCTS1-790H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Malignant T-cell-amplified sequence 1(MCTS1) - CSB-YP892143HU CSB-BP892143HU CSB-MP892143HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Malignant T-cell-amplified sequence 1 - CSB-EP892143HU from Cusabio Category Protein Source E.coli Species Human

MCTS1, 1-181aa, Human, His tag, E.coli - ATGP1995 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Malignant T-Cell-Amplified Sequence 1 Protein (Recombinant) - abx261032 from Abbexa Category Protein

MCTS1 (transcript variant 1) - TP300224 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MCTS1, Peptide - MBS427758 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Pig, Bovine

MCTS1 Protein - NBP2-47381PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

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