MASP1

Gene Symbol	MASP1
Entrez Gene	5648
Alt Symbol	3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF
Species	Human
Gene Type	protein-coding
Description	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Other Description	Ra-reactive factor serine protease p100|complement factor MASP-3|complement-activating component of Ra-reactive factor|mannan-binding lectin serine protease 1|mannose-binding lectin-associated serine protease 1|mannose-binding protein-associated serine protease|serine protease 5
Swissprots	Q9UF09 Q96RS4 Q68D21 Q8IUV8 P48740 O95570 A8K542 B4E2L7 A8K6M1
Accessions	BAA34864 BAA89206 EAW78150 EAW78151 EAW78152 EAW78153 P48740 AF284421 AAK84071 AI278088 AI828640 AK129893 AK291157 BAF83846 AK291686 BAF84375 AK300663 BAG62349 AK304334 BAG65179 AL134380 AL137646 CAB70856 AL708781 AV686235 BC039724 AAH39724 BC106945 AAI06946 BC106946 AAI06947 BX641029 CAE46018 BX647237 CAI46037 CB162101 CR749615 CAH18409 DC423174 XM_006713700 XP_006713763 XM_006713701 XP_006713764 XM_011512989 XP_011511291 XM_011512990 XP_011511292 XM_011512991 XP_011511293 NM_001031849 NP_001027019 NM_001879 NP_001870 NM_139125 NP_624302 NR_033519
Function	Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. {ECO:0000269|PubMed:11485744}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11485744}.
Tissue Specificity	Protein of the plasma which is primarily expressed by liver. {ECO:0000269|PubMed:11485744, ECO:0000269|PubMed:8018603, ECO:0000269|PubMed:8240317, ECO:0000269|PubMed:9367419}.
Top Pathways	Complement and coagulation cascades, Staphylococcus aureus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MASP1 293T Cell Transient Overexpression Lysate(Denatured) - H00005648-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MASP1 overexpression lysate - LY400702 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MASP1 overexpression lysate - LY408424 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MASP1 overexpression lysate - LY422206 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MASP1 293 Cell Lysate - 400683 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

MASP1 293 Cell Lysate - 404635 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Complement Factor MASP3/MASP1 Overexpression Lysate (Native) - NBL1-12905 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Complement Factor MASP3/MASP1 Overexpression Lysate (Native) - NBP2-05611 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

MASP1 Over-expression Lysate Product - GWB-9B3942 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

MASP1 Over-expression Lysate Product - GWB-2DCAB7 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Complement Factor MASP3/MASP1 Overexpression Lysate (Denatured) - H00005648-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human MASP1 Knockdown Stable Cell Line - CSC-DC009246 from Creative biogene Category Cell Line Species Human

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