MASP1

Gene Symbol	MASP1
Entrez Gene	5648
Alt Symbol	3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF
Species	Human
Gene Type	protein-coding
Description	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Other Description	Ra-reactive factor serine protease p100|complement factor MASP-3|complement-activating component of Ra-reactive factor|mannan-binding lectin serine protease 1|mannose-binding lectin-associated serine protease 1|mannose-binding protein-associated serine protease|serine protease 5
Swissprots	Q9UF09 Q96RS4 Q68D21 Q8IUV8 P48740 O95570 A8K542 B4E2L7 A8K6M1
Accessions	BAA34864 BAA89206 EAW78150 EAW78151 EAW78152 EAW78153 P48740 AF284421 AAK84071 AI278088 AI828640 AK129893 AK291157 BAF83846 AK291686 BAF84375 AK300663 BAG62349 AK304334 BAG65179 AL134380 AL137646 CAB70856 AL708781 AV686235 BC039724 AAH39724 BC106945 AAI06946 BC106946 AAI06947 BX641029 CAE46018 BX647237 CAI46037 CB162101 CR749615 CAH18409 DC423174 XM_006713700 XP_006713763 XM_006713701 XP_006713764 XM_011512989 XP_011511291 XM_011512990 XP_011511292 XM_011512991 XP_011511293 NM_001031849 NP_001027019 NM_001879 NP_001870 NM_139125 NP_624302 NR_033519
Function	Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. {ECO:0000269|PubMed:11485744}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11485744}.
Tissue Specificity	Protein of the plasma which is primarily expressed by liver. {ECO:0000269|PubMed:11485744, ECO:0000269|PubMed:8018603, ECO:0000269|PubMed:8240317, ECO:0000269|PubMed:9367419}.
Top Pathways	Complement and coagulation cascades, Staphylococcus aureus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MASP1 full length protein - ab159246 from Abcam Category Protein Source Wheat germ Species Human

MASP1 / MASP Antibody Blocking Peptide - LS-E5606 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MASP1 / MASP Antibody Blocking Peptide - LS-E23293 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Complement Factor MASP3/MASP1 Recombinant Protein - H00005648-P01 from Novus Biologicals Category Protein Species Human

MASP1-Antibody-Center-Blocking-Peptide - BP18135c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Complement MASP3 Catalytic Domain, CF - 1724-SE-020 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ile450-Val721, with an N-terminal signal peptide and a C-terminal 10-His tag

Human MASP1 protein - orb180339 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

MAP1 Blocking Peptide - 33R-10883 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

MASP-1 - H00005648-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MASP-1 - H00005648-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MASP1 fusion protein - ag16432 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MASP1 fusion protein - Ag18657 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MASP1 fusion protein - ag18820 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MASP1 Enzyme - BP001778-C655 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human MASP1, His-tagged - MASP1-754H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human MASP1, GST-tagged - MASP1-755H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Mannose Associated Serine Protease 1 (MASP1) - RPB895Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mannose Associated Serine Protease 1 (MASP1) - RPB895Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mannose Associated Serine Protease 1 (MASP1) - RPB895Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

MASP1 HC Blocking Peptide - CBP1957 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

MASP1 LC Blocking Peptide - CBP3653 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Mannose Associated Serine Protease 1 (MASP1) - RPB895Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Mannan-binding lectin serine protease 1(MASP1) - CSB-YP013508HU CSB-EP013508HU CSB-BP013508HU CSB-MP013508HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Complement MASP3 Catalytic Domain, CF - 1724-SE from R&D Systems Category Protein Prices $329.00 Sizes 20 µg Source Mouse myeloma cell line, NS0-derived Ile450-Val721, with an N-terminal signal peptide and a C-terminal 10-His tag Species Human

MASP1 Protein - abx164192 from Abbexa Category Protein Species Human, Mouse, Rat

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