MASP1

Gene Symbol MASP1
Entrez Gene 5648
Alt Symbol 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF
Species Human
Gene Type protein-coding
Description mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Other Description Ra-reactive factor serine protease p100|complement factor MASP-3|complement-activating component of Ra-reactive factor|mannan-binding lectin serine protease 1|mannose-binding lectin-associated serine protease 1|mannose-binding protein-associated serine protease|serine protease 5
Swissprots Q9UF09 Q96RS4 Q68D21 Q8IUV8 P48740 O95570 A8K542 B4E2L7 A8K6M1
Accessions BAA34864 BAA89206 EAW78150 EAW78151 EAW78152 EAW78153 P48740 AF284421 AAK84071 AI278088 AI828640 AK129893 AK291157 BAF83846 AK291686 BAF84375 AK300663 BAG62349 AK304334 BAG65179 AL134380 AL137646 CAB70856 AL708781 AV686235 BC039724 AAH39724 BC106945 AAI06946 BC106946 AAI06947 BX641029 CAE46018 BX647237 CAI46037 CB162101 CR749615 CAH18409 DC423174 XM_006713700 XP_006713763 XM_006713701 XP_006713764 XM_011512989 XP_011511291 XM_011512990 XP_011511292 XM_011512991 XP_011511293 NM_001031849 NP_001027019 NM_001879 NP_001870 NM_139125 NP_624302 NR_033519
Function Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. {ECO:0000269|PubMed:11485744}.
Subcellular Location Secreted {ECO:0000269|PubMed:11485744}.
Tissue Specificity Protein of the plasma which is primarily expressed by liver. {ECO:0000269|PubMed:11485744, ECO:0000269|PubMed:8018603, ECO:0000269|PubMed:8240317, ECO:0000269|PubMed:9367419}.
Top Pathways Complement and coagulation cascades, Staphylococcus aureus infection

MASP-1 CRISPR/Cas9 KO Plasmid (h) - sc-403583 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1 HDR Plasmid (h) - sc-403583-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1 Double Nickase Plasmid (h) - sc-403583-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1 Double Nickase Plasmid (h2) - sc-403583-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1 CRISPR Activation Plasmid (h) - sc-403583-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1 CRISPR Activation Plasmid (h2) - sc-403583-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1 Lentiviral Activation Particles (h) - sc-403583-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1 Lentiviral Activation Particles (h2) - sc-403583-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MASP-1/3 siRNA (h) - sc-45349 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MASP-1/3 shRNA Plasmid (h) - sc-45349-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MASP-1/3 shRNA (h) Lentiviral Particles - sc-45349-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Complement Factor MASP3/MASP1 RNAi - H00005648-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Complement Factor MASP3/MASP1 RNAi - H00005648-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU092381 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13053 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13053 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MASP1 siRNA (Human) - CRH3806 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Complement Factor MASP3/MASP1 RNAi - H00005648-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MASP1 (NM_001879.5) - SHH338479 from Creative biogene

Category siRNA
Species Reactivities Human

MASP1 shRNA Plasmid (Human) - CHH3806 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MASP1 miRNA 3'UTR clone - MiUTR3H-03438 from Creative biogene

Species Reactivities Human

MASP1 miRNA 3'UTR clone - MiUTR3H-03439 from Creative biogene

Species Reactivities Human

MASP1 miRNA 3'UTR clone - MiUTR3H-03440 from Creative biogene

Species Reactivities Human
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