HIBCH

Gene Symbol HIBCH
Entrez Gene 26275
Alt Symbol HIBYLCOAH
Species Human
Gene Type protein-coding
Description 3-hydroxyisobutyryl-CoA hydrolase
Other Description 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial|3-hydroxyisobutyryl-Coenzyme A hydrolase|HIB-CoA hydrolase|HIBYL-CoA-H
Swissprots Q53RF7 Q53GF2 Q53GA8 Q53TC6 D3DPI4 Q6NVY1 Q92931 Q9BS94
Accessions AAX93234 AAY24178 EAX10873 EAX10874 EAX10875 EAX10876 EAX10877 Q6NVY1 AI767349 AK126890 AK222979 BAD96699 AK223023 BAD96743 AK308042 AK313651 BC005190 AAH05190 BC067822 AAH67822 BI764401 BP193393 CA448468 CA453768 DB034438 U66669 AAC52114 XM_011510953 XP_011509255 XM_011510954 XP_011509256 XR_922903 NM_014362 NP_055177 NM_198047 NP_932164
Function Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}.
Subcellular Location Mitochondrion {ECO:0000250}.
Tissue Specificity Highly expressed in liver and kidney, also detected in heart, muscle and brain (at protein level). Not detected in lung. {ECO:0000269|PubMed:8824301}.
Top Pathways Carbon metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, Propanoate metabolism

HIBCH (A-18) - sc-243023 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HIBCH (A-18): sc-243023. Western blot analysis of HIBCH expression in K-562 (A), RT-4 (B) and MOLT-4 (C) whole cell lysates and human tonsil tissue extract (D).

HIBCH (S-18) - sc-243022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HIBCH (S-18): sc-243022. Western blot analysis of HIBCH expression in Jurkat (A), K-562 (B), RT-4 (C), WiDR (D) and CCRF-CEM (E) whole cell lysates and human tonsil tissue extract (F).

Anti-HIBCH antibody - ab153826 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HIBCH antibody (ab153826) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : HepG2 whole cell lysateLane 3 : Molt4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-HIBCH antibody - ab82413 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HIBCH antibody (ab82413) at 1/50 dilution + HepG2 cell line lysates at 12.5 µg

Anti-HIBCH antibody - ab101672 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HIBCH antibody (ab101672) at 1/1000 dilutionLane 1 : HepG2 lysateLane 2 : Human fetal liver lysateLane 3 : Human fetal kidney lysateLane 4 : Human fetal heart lysateLane 5 : Human fetal brain lysateLane 6 : Human fetal skeletal muscle lysate

Anti-HIBCH Antibody (aa183-209) - LS-C100636 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with HIBCH antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-HIBCH Antibody (clone 3F6) - LS-C115329 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F6
Anti-HIBCH mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HIBCH.

Anti-HIBCH Antibody (clone 5C5) IHC-plus™ - LS-B9997 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 5C5
Anti-HIBCH antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9997 concentration 10 ug/ml.

Anti-HIBCH Antibody (clone 3B10) - LS-C115314 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B10
Anti-HIBCH mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HIBCH.

Anti-HIBCH Antibody (clone 2A5) - LS-C115316 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A5
Anti-HIBCH mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HIBCH.

Anti-HIBCH Antibody (clone 3H5) - LS-C115315 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H5
IHC of paraffin-embedded Human Kidney tissue using anti-HIBCH mouse monoclonal antibody. (Dilution 1:50).

Anti-HIBCH Antibody (clone 1C7) - LS-C115317 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C7
Anti-HIBCH mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HIBCH.

HIBCH Antibody (3H5) - NBP2-02673 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H5
Western Blot: HIBCH Antibody (3H5) [NBP2-02673] Analysis of extracts (35ug) from 9 different cell lines by using anti-HIBCH monoclonal antibody.

HIBCH Antibody - NBP2-32669 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HIBCH Antibody [NBP2-32669] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-264

HIBCH Antibody - NBP1-32964 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HIBCH Polyclonal Antibody - bs-15484R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIBCH antibody produced in rabbit - HPA036541 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HIBCH: <B>Cat. No. HPA036541</B>: Immunohistochemical staining of Human kidney shows strong granular cytoplasmic positivity in cells in tubules.

Anti-HIBCH (C-term) antibody produced in rabbit - SAB1300865 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HIBCH (C-term) Antibody: <B>Cat. No. SAB1300865</B>: HIBCH in CEM cell line lysates with Anti-HIBCH (C-term) Antibody at 4.0 μg/mL.

Anti-HIBCH antibody produced in rabbit - HPA036540 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HIBCH: <B>Cat. No. HPA036540</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Monoclonal Anti-HIBCH antibody produced in mouse - SAB4100120 from Sigma-Aldrich

Prices $358.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone HIBCH-B64
<B>Immunofluorescence</B><BR/>A549 cells were fixed and permeabilized with cold methanol followed by aceton. Fixed cells were stained with Mouse Anti- HIBCH Clone: HIBCH-B64 (<B>Cat. No. SAB4100120</B>) diluted to 1:20. The antibody was developed using Goat Anti-Mouse IgG, Cy3 conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.

Anti-HIBCH (351-365) antibody produced in rabbit - SAB1101269 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-HIBCH (351-365) (RB): <B>Cat. No. SAB1101269</B>: Immunofluorescence of HUVEC cells using HIBCH (351-365) (RB), Cat. No. SAB1101269 (red) at a 1:200 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

HIBCH-Antibody-Center - AP7435c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of HIBCH Antibody (Center) (Cat. #AP7435c) in K562 cell line lysates (35ug/lane). HIBCH (arrow) was detected using the purified Pab.(2ug/ml)

HIBCH Antibody - middle region (OAAB04461) - OAAB04461 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

HIBCH antibody - GTX109167 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-HIBCH antibody used in ICC/IF. GTX109167

HIBCH antibody [1C7] - GTX84362 from GeneTex

Prices $329.00
Sizes 100 μl
Host Mouse
Clonality Monoclonal
Clone 1C7
Anti-HIBCH antibody [1C7] used in Flow cytometry/FACS. GTX84362
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