| Gene Symbol |
SMURF1
|
| Entrez Gene |
57154
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMAD specific E3 ubiquitin protein ligase 1
|
| Other Description |
E3 ubiquitin ligase SMURF1|E3 ubiquitin-protein ligase SMURF1|SMAD-specific E3 ubiquitin-protein ligase 1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1|hSMURF1
|
| Swissprots |
Q9UJT8 B9EGV3 O75853 B7ZMB6 A4D279 Q547Q3 Q9HCE7
|
| Accessions |
AAC62434 EAL23885 EAL23886 EAW76686 EAW76687 EAW76688 EAW76689 EAW76690 Q9HCE7 AB046845 BAB13451 AF199364 AAF08298 AF464850 AAM90910 AK057024 AK126471 AL833673 AL834242 CAD38919 AY007164 BC008574 BC136804 AAI36805 BC144414 AAI44415 BC152468 AAI52469 BM981719 DB727777 XM_011516418 XP_011514720 XM_011516419 XP_011514721 XM_011516420 XP_011514722 XM_011516421 XP_011514723 NM_001199847 NP_001186776 NM_020429 NP_065162 NM_181349 NP_851994
|
| Function |
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis
|