SMURF1

Gene Symbol SMURF1
Entrez Gene 57154
Alt Symbol -
Species Human
Gene Type protein-coding
Description SMAD specific E3 ubiquitin protein ligase 1
Other Description E3 ubiquitin ligase SMURF1|E3 ubiquitin-protein ligase SMURF1|SMAD-specific E3 ubiquitin-protein ligase 1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1|hSMURF1
Swissprots Q9UJT8 B9EGV3 O75853 B7ZMB6 A4D279 Q547Q3 Q9HCE7
Accessions AAC62434 EAL23885 EAL23886 EAW76686 EAW76687 EAW76688 EAW76689 EAW76690 Q9HCE7 AB046845 BAB13451 AF199364 AAF08298 AF464850 AAM90910 AK057024 AK126471 AL833673 AL834242 CAD38919 AY007164 BC008574 BC136804 AAI36805 BC144414 AAI44415 BC152468 AAI52469 BM981719 DB727777 XM_011516418 XP_011514720 XM_011516419 XP_011514721 XM_011516420 XP_011514722 XM_011516421 XP_011514723 NM_001199847 NP_001186776 NM_020429 NP_065162 NM_181349 NP_851994
Function E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
Top Pathways Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

Smurf1 Antibody - 2174 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Smurf1 Antibody.

Smurf1 (C-20) - sc-14908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Smurf1 (F-20) - sc-14906 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Smurf1 (H-60) - sc-25510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Smurf1 (H-60): sc-25510. Western blot analysis of Smurf1 expression in mouse kidney tissue extract.

Smurf1 (L-15) - sc-5731 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Smurf1 (L-15): sc-5731. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic and nuclear staining of cells in seminiferous ducts and Leydig cells.

Smurf1 (C-16) - sc-5732 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Smurf1 (X-25) - sc-130877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Smurf1 (X-25): sc-130877. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.

Smurf1 (45-K) - sc-100616 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Smurf1 (45-K): sc-100616. Western blot analysis of Smurf1 expression in HeLa whole cell lysate.

Anti-SMURF1 antibody - ab57573 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
SMURF1 antibody (ab57573) used in immunohistochemistry at 2ug/ml on formalin fixed and paraffin embedded human stomach.

Anti-SMURF1 antibody - ab199159 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling SMURF1 with ab199159 at 1/15 dilution.

Anti-SMURF1 antibody [1D7] - ab117552 from Abcam

Prices $385.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1D7
ELISA of the detection limit for recombinant proprietary tagged SMURF1 is approximately 0.1ng/ml as a capture antibody (ab117552).

Anti-SMURF1 antibody - ab38866 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SMURF1 antibody (ab38866) at 1/100 dilution + mouse kidney tissue lysate at 35 µg

Anti-SMURF1 antibody - ab115601 from Abcam

Prices $378.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab115601, at 10µg/ml, staining SMURF1 in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SMURF1 antibody - ab94480 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SMURF1 antibody (ab94480) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : U2OS (Human osteosarcoma cell line) Whole Cell LysateLane 3 : MG-63 (Human osteosarcoma cell line) Whole Cell LysateLane 4 : Bone (Human) Tissue Lysate - tumor tissue (ab29359)Lane 5 : Saos 2 (Human epithelial-like osteosarcoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SMURF1 antibody - ab40823 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SMURF1 Antibody (aa718-747, APC) - LS-C241023 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa718-747, Biotin) - LS-C241025 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa718-747, FITC) - LS-C241026 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa352-381, APC) - LS-C241028 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa718-747, PE) - LS-C241027 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa352-381, Biotin) - LS-C241031 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa352-381, AP) - LS-C241029 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa352-381, FITC) - LS-C241030 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa352-381, PE) - LS-C241032 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF1 Antibody (aa74-104, AP) - LS-C241033 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more