SMURF1

Gene Symbol	SMURF1
Entrez Gene	57154
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SMAD specific E3 ubiquitin protein ligase 1
Other Description	E3 ubiquitin ligase SMURF1|E3 ubiquitin-protein ligase SMURF1|SMAD-specific E3 ubiquitin-protein ligase 1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1|hSMURF1
Swissprots	Q9UJT8 B9EGV3 O75853 B7ZMB6 A4D279 Q547Q3 Q9HCE7
Accessions	AAC62434 EAL23885 EAL23886 EAW76686 EAW76687 EAW76688 EAW76689 EAW76690 Q9HCE7 AB046845 BAB13451 AF199364 AAF08298 AF464850 AAM90910 AK057024 AK126471 AL833673 AL834242 CAD38919 AY007164 BC008574 BC136804 AAI36805 BC144414 AAI44415 BC152468 AAI52469 BM981719 DB727777 XM_011516418 XP_011514720 XM_011516419 XP_011514721 XM_011516420 XP_011514722 XM_011516421 XP_011514723 NM_001199847 NP_001186776 NM_020429 NP_065162 NM_181349 NP_851994
Function	E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
Top Pathways	Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMURF1 overexpression lysate - LY403618 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

SMURF1 overexpression lysate - LY412480 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

SMURF1 overexpression lysate - LY429622 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

SMURF1 293 Cell Lysate - 403123 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

SMURF1 Overexpression Lysate (Native) - NBP2-06648 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

SMURF1 Over-expression Lysate Product - GWB-BCC250 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

SMURF1 Overexpression Lysate (Native) - NBL1-16259 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

SMURF1 Overexpression Lysate (Native) - NBP2-09895 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

SMURF1 Overexpression Lysate (Denatured) - H00057154-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human SMURF1 Knockdown Stable Cell Line - CSC-DC014783 from Creative biogene Category Cell Line Species Human

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