SMURF1

Gene Symbol	SMURF1
Entrez Gene	57154
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SMAD specific E3 ubiquitin protein ligase 1
Other Description	E3 ubiquitin ligase SMURF1|E3 ubiquitin-protein ligase SMURF1|SMAD-specific E3 ubiquitin-protein ligase 1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1|hSMURF1
Swissprots	Q9UJT8 B9EGV3 O75853 B7ZMB6 A4D279 Q547Q3 Q9HCE7
Accessions	AAC62434 EAL23885 EAL23886 EAW76686 EAW76687 EAW76688 EAW76689 EAW76690 Q9HCE7 AB046845 BAB13451 AF199364 AAF08298 AF464850 AAM90910 AK057024 AK126471 AL833673 AL834242 CAD38919 AY007164 BC008574 BC136804 AAI36805 BC144414 AAI44415 BC152468 AAI52469 BM981719 DB727777 XM_011516418 XP_011514720 XM_011516419 XP_011514721 XM_011516420 XP_011514722 XM_011516421 XP_011514723 NM_001199847 NP_001186776 NM_020429 NP_065162 NM_181349 NP_851994
Function	E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
Top Pathways	Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SMURF1 protein fragment - ab95928 from Abcam Category Protein Prices $396.00 Sizes 20 µg Source Baculovirus Species Human

Human SMURF1 full length protein - ab153442 from Abcam Category Protein Source Wheat germ Species Human

Human SMURF1 protein fragment - ab153443 from Abcam Category Protein Source Wheat germ Species Human

SMURF1 peptide - ab107712 from Abcam Category Peptide

SMURF1 peptide (359-372) - ab45831 from Abcam Category Peptide Species Human

SMURF1 Antibody Blocking Peptide - LS-E3746 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMURF1 Antibody Blocking Peptide - LS-E6852 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMURF1 Antibody Blocking Peptide - LS-E6853 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMURF1 Antibody Blocking Peptide - LS-E25974 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMURF1 Recombinant Protein - H00057154-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human SMURF1 Protein - H00057154-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMURF1 Peptide - P0868 from Novus Biologicals Category Peptide Species Human

SMURF1 Peptide - P0867 from Novus Biologicals Category Peptide Species Human

SMURF1-Antibody-Center-Blocking-Peptide - BP14957c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMURF1-Antibody-C-term-Blocking-Peptide - BP2104b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMURF1-Antibody-N-term-Blocking-Peptide - BP2104a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMURF1 blocking peptide - GTX89472-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

SMURF1 Peptide - AC21-0801-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SMURF1 - H00057154-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SMURF1 - H00057154-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMURF1 - H00057154-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMURF1 Peptide - 46-391P from ProSci Category Peptide

SMURF1 Peptide - 7945P from ProSci Category Peptide Species Human

SMURF1 Peptide - 350487 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

SMURF1, Active Human Recombinant Protein - GWB-FF1056 from Genway Biotech Category Protein Prices $485.00 Sizes 20 µg Species Human

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