SMURF1

Gene Symbol SMURF1
Entrez Gene 57154
Alt Symbol -
Species Human
Gene Type protein-coding
Description SMAD specific E3 ubiquitin protein ligase 1
Other Description E3 ubiquitin ligase SMURF1|E3 ubiquitin-protein ligase SMURF1|SMAD-specific E3 ubiquitin-protein ligase 1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1|hSMURF1
Swissprots Q9UJT8 B9EGV3 O75853 B7ZMB6 A4D279 Q547Q3 Q9HCE7
Accessions AAC62434 EAL23885 EAL23886 EAW76686 EAW76687 EAW76688 EAW76689 EAW76690 Q9HCE7 AB046845 BAB13451 AF199364 AAF08298 AF464850 AAM90910 AK057024 AK126471 AL833673 AL834242 CAD38919 AY007164 BC008574 BC136804 AAI36805 BC144414 AAI44415 BC152468 AAI52469 BM981719 DB727777 XM_011516418 XP_011514720 XM_011516419 XP_011514721 XM_011516420 XP_011514722 XM_011516421 XP_011514723 NM_001199847 NP_001186776 NM_020429 NP_065162 NM_181349 NP_851994
Function E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
Top Pathways Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

Smurf1 CRISPR/Cas9 KO Plasmid (h) - sc-401196 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 HDR Plasmid (h) - sc-401196-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 Double Nickase Plasmid (h) - sc-401196-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 Double Nickase Plasmid (h2) - sc-401196-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 CRISPR Activation Plasmid (h) - sc-401196-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 CRISPR Activation Plasmid (h2) - sc-401196-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 Lentiviral Activation Particles (h) - sc-401196-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 Lentiviral Activation Particles (h2) - sc-401196-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 siRNA (h) - sc-41673 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smurf1 shRNA Plasmid (h) - sc-41673-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smurf1 shRNA (h) Lentiviral Particles - sc-41673-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMURF1 RNAi - H00057154-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SMURF1 RNAi - H00057154-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SMURF1 RNAi - H00057154-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU125831 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19813 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19813 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13866 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13866

SMURF1 siRNA (Human) - CRJ1363 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMURF1 RNAi - H00057154-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SMURF1 - MBS8204662 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Smurf1 CRISPR/Cas9 KO Plasmid (h2) - sc-401196-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf1 HDR Plasmid (h2) - sc-401196-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SMURF1 (NM_020429.2) - SHH413744 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMURF1 siRNA - orb271864 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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