POT1

Gene Symbol	POT1
Entrez Gene	25913
Alt Symbol	CMM10, HPOT1
Species	Human
Gene Type	protein-coding
Description	protection of telomeres 1
Other Description	POT1-like telomere end-binding protein|protection of telomeres 1 homolog|protection of telomeres protein 1
Swissprots	O95018 Q9NW19 Q9H662 Q9UG95 Q5MJ36 Q9NUX5
Accessions	AAD08852 CAE89907 CAE91483 EAW83615 EAW83616 EAW83617 Q9NUX5 AK001230 BAA91568 AK001935 BAA91988 AK022580 BAB14110 AK026234 BAB15404 AK302263 BAH13661 AL050120 CAB43281 AY823520 AAW22613 AY823521 AAW22614 AY823522 AAW22615 AY823523 AAW22616 AY823524 AAW22617 BC002923 AAH02923 BM693856 DA412639 DA580630 DA707481 DQ892765 ABM83691 DQ896010 ABM87009 XM_006715917 XP_006715980 XM_011516006 XP_011514308 XM_011516007 XP_011514309 NM_001042594 NP_001036059 NM_015450 NP_056265 NR_003102 NR_003103 NR_003104
Function	Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high
Subcellular Location	Nucleus {ECO:0000269|PubMed:12391173}. Chromosome, telomere {ECO:0000269|PubMed:12391173}. Note=Colocalizes with telomeric DNA.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11349150, ECO:0000269|PubMed:12391173}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

POT1 (H-200) - sc-33789 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

POT1 (M1-P1H5) - sc-81711 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

POT1 (C-19) - sc-27952 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

POT1 (L-18) - sc-27951 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-POT1 antibody - ab21382 from Abcam Prices $398.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POT1 antibody - ab90552 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 antibody - ab194480 from Abcam Prices $376.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-POT1 antibody - ab67298 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 antibody - ab47082 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POT1 antibody [EPR6319] - ab124784 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6319

Anti-POT1 Antibody (Internal) - LS-C92035 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (aa200-300) - LS-C2849 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (aa450-500) - LS-C19340 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (Internal, Biotin) - LS-C142239 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (Internal, DY650) - LS-C142240 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (Internal, DY488) - LS-C142241 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (Internal, HRP) - LS-C142242 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (Internal, DY550) - LS-C142243 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody - LS-C191607 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (aa251-300) - LS-C116786 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (aa251-300) - LS-C116785 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (Internal, clone EPR6319) - LS-C138917 from LifeSpan Bioscience Prices $480.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6319

Anti-POT1 Antibody (C-Terminus) - LS-C345698 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (Asn296) - LS-C177283 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POT1 Antibody (aa247-296) - LS-C199973 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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