POT1
| Gene Symbol | POT1 |
|---|---|
| Entrez Gene | 25913 |
| Alt Symbol | CMM10, HPOT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protection of telomeres 1 |
| Other Description | POT1-like telomere end-binding protein|protection of telomeres 1 homolog|protection of telomeres protein 1 |
| Swissprots | O95018 Q9NW19 Q9H662 Q9UG95 Q5MJ36 Q9NUX5 |
| Accessions | AAD08852 CAE89907 CAE91483 EAW83615 EAW83616 EAW83617 Q9NUX5 AK001230 BAA91568 AK001935 BAA91988 AK022580 BAB14110 AK026234 BAB15404 AK302263 BAH13661 AL050120 CAB43281 AY823520 AAW22613 AY823521 AAW22614 AY823522 AAW22615 AY823523 AAW22616 AY823524 AAW22617 BC002923 AAH02923 BM693856 DA412639 DA580630 DA707481 DQ892765 ABM83691 DQ896010 ABM87009 XM_006715917 XP_006715980 XM_011516006 XP_011514308 XM_011516007 XP_011514309 NM_001042594 NP_001036059 NM_015450 NP_056265 NR_003102 NR_003103 NR_003104 |
| Function | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12391173}. Chromosome, telomere {ECO:0000269|PubMed:12391173}. Note=Colocalizes with telomeric DNA. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11349150, ECO:0000269|PubMed:12391173}. |
POT1 CRISPR/Cas9 KO Plasmid (h) - sc-403275 from Santa Cruz Biotechnology
|
||||||||
POT1 HDR Plasmid (h) - sc-403275-HDR from Santa Cruz Biotechnology
|
||||||||
POT1 Double Nickase Plasmid (h) - sc-403275-NIC from Santa Cruz Biotechnology
|
||||||||
POT1 Double Nickase Plasmid (h2) - sc-403275-NIC-2 from Santa Cruz Biotechnology
|
||||||||
POT1 CRISPR Activation Plasmid (h) - sc-403275-ACT from Santa Cruz Biotechnology
|
||||||||
POT1 CRISPR Activation Plasmid (h2) - sc-403275-ACT-2 from Santa Cruz Biotechnology
|
||||||||
POT1 Lentiviral Activation Particles (h) - sc-403275-LAC from Santa Cruz Biotechnology
|
||||||||
POT1 Lentiviral Activation Particles (h2) - sc-403275-LAC-2 from Santa Cruz Biotechnology
|
||||||||
POT1 siRNA (h) - sc-44032 from Santa Cruz Biotechnology
|
||||||||
POT1 shRNA Plasmid (h) - sc-44032-SH from Santa Cruz Biotechnology
|
||||||||
POT1 shRNA (h) Lentiviral Particles - sc-44032-V from Santa Cruz Biotechnology
|
||||||||
POT1 RNAi - H00025913-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU081111 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17161 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17161 from Sigma-Aldrich
|
||||||||
POT1 siRNA (Human) - CRH8584 from Cohesion Biosciences
|
||||||||
shRNA set against Human POT1 (NM_015450.2) - SHH379920 from Creative biogene
|
||||||||
shRNA set against Human POT1(NM_015450.2) - SHR129498 from Creative biogene
|
||||||||
shRNA set against Human POT1(NM_001042594.1) - SHR129516 from Creative biogene
|
||||||||
POT1 shRNA Plasmid (Human) - CHH8584 from Cohesion Biosciences
|
||||||||
POT1 miRNA 3'UTR clone - MiUTR1H-08106 from Creative biogene
|
||||||||
POT1 miRNA 3'UTR clone - MiUTR1H-08107 from Creative biogene
|