POT1

Gene Symbol POT1
Entrez Gene 25913
Alt Symbol CMM10, HPOT1
Species Human
Gene Type protein-coding
Description protection of telomeres 1
Other Description POT1-like telomere end-binding protein|protection of telomeres 1 homolog|protection of telomeres protein 1
Swissprots O95018 Q9NW19 Q9H662 Q9UG95 Q5MJ36 Q9NUX5
Accessions AAD08852 CAE89907 CAE91483 EAW83615 EAW83616 EAW83617 Q9NUX5 AK001230 BAA91568 AK001935 BAA91988 AK022580 BAB14110 AK026234 BAB15404 AK302263 BAH13661 AL050120 CAB43281 AY823520 AAW22613 AY823521 AAW22614 AY823522 AAW22615 AY823523 AAW22616 AY823524 AAW22617 BC002923 AAH02923 BM693856 DA412639 DA580630 DA707481 DQ892765 ABM83691 DQ896010 ABM87009 XM_006715917 XP_006715980 XM_011516006 XP_011514308 XM_011516007 XP_011514309 NM_001042594 NP_001036059 NM_015450 NP_056265 NR_003102 NR_003103 NR_003104
Function Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high
Subcellular Location Nucleus {ECO:0000269|PubMed:12391173}. Chromosome, telomere {ECO:0000269|PubMed:12391173}. Note=Colocalizes with telomeric DNA.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:11349150, ECO:0000269|PubMed:12391173}.

POT1-Over-expression-Lysate - LY15252a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag POT1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 2) or transiently transfected with thePOT1 gene

POT1 293 Cell Lysate - 402131 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

POT1 Overexpression Lysate (Native) - NBL1-14614 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: POT1 Overexpression Lysate (Adult Normal) [NBL1-14614] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for POT1.

POT1 Over-expression Lysate Product - GWB-39BB0F from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human POT1 Knockdown Stable Cell Line - CSC-DC012137 from Creative biogene

Category Cell Line
Species Human
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