POT1

Gene Symbol	POT1
Entrez Gene	25913
Alt Symbol	CMM10, HPOT1
Species	Human
Gene Type	protein-coding
Description	protection of telomeres 1
Other Description	POT1-like telomere end-binding protein|protection of telomeres 1 homolog|protection of telomeres protein 1
Swissprots	O95018 Q9NW19 Q9H662 Q9UG95 Q5MJ36 Q9NUX5
Accessions	AAD08852 CAE89907 CAE91483 EAW83615 EAW83616 EAW83617 Q9NUX5 AK001230 BAA91568 AK001935 BAA91988 AK022580 BAB14110 AK026234 BAB15404 AK302263 BAH13661 AL050120 CAB43281 AY823520 AAW22613 AY823521 AAW22614 AY823522 AAW22615 AY823523 AAW22616 AY823524 AAW22617 BC002923 AAH02923 BM693856 DA412639 DA580630 DA707481 DQ892765 ABM83691 DQ896010 ABM87009 XM_006715917 XP_006715980 XM_011516006 XP_011514308 XM_011516007 XP_011514309 NM_001042594 NP_001036059 NM_015450 NP_056265 NR_003102 NR_003103 NR_003104
Function	Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high
Subcellular Location	Nucleus {ECO:0000269|PubMed:12391173}. Chromosome, telomere {ECO:0000269|PubMed:12391173}. Note=Colocalizes with telomeric DNA.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11349150, ECO:0000269|PubMed:12391173}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POT1 peptide - ab23432 from Abcam Category Peptide

Human POT1 protein fragment - ab112404 from Abcam Category Protein Source Wheat germ Species Human

POT1 Antibody Blocking Peptide - LS-E21330 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POT1 Antibody Blocking Peptide - LS-E21329 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human POT1 Protein - H00025913-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

POT1 Blocking Peptide - NB500-176PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

POT1 peptide - orb218468 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

POT1 Blocking Peptide - abx063799 from Abbexa Category Peptide Species Human, Monkey

POT1 - H00025913-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

POT1 - H00025913-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POT1 fusion protein - ag0875 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human POT1 - POT1-27935TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Protection Of Telomeres 1 Homolog (POT1) - RPK108Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

POT1 Blocking Peptide - CBP2605 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

POT1 (N296) Peptide - BS2933P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Protection Of Telomeres 1 Homolog (POT1) - RPK108Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Protection of telomeres protein 1(POT1) - CSB-YP868326HU CSB-EP868326HU CSB-BP868326HU CSB-MP868326HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POT1 (transcript variant 1) - TP316275 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Protection of telomeres protein 1 (POT1), Recombinant Protein - MBS1407194 from MyBioSource Category Protein Prices $1,430.00, $1,430.00, $1,660.00, $1,660.00, $2,425.00, $2,425.00, $2,870.00, $2,870.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

POT1 Peptide, Human - M34GP12137H from Creative Peptides Category Peptide Source Synthetic. Species Human

POT1 Recombinant Protein Antigen - NBP2-57891PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human POT1 Protein, GST-tagged - POT1-2787H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human POT1 Protein, Flag-tagged - POT1-2788H from Creative Biomart Category Protein Source HEK293 Species Human

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