| Gene Symbol |
PAPPA2
|
| Entrez Gene |
60676
|
| Alt Symbol |
PAPP-A2, PAPP-E, PAPPE, PLAC3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pappalysin 2
|
| Other Description |
pappalysin-2|placenta-specific 3|pregnancy-associated plasma preproprotein-A2|pregnancy-associated plasma protein E1
|
| Swissprots |
A9Z1Y8 Q9BXP8 Q96PH7 Q96PH8 Q9H4C9
|
| Accessions |
CAD35982 CCD35052 EAW91003 EAW91004 Q9BXP8 AB209369 BAD92606 AF311940 AAK31073 AF342989 AAL17779 AF342990 AAL17780 AJ278348 CAC11134 AK096718 BC062665 BC104644 BC117193 AAI17194 BC117195 AAI17196 BC152552 BC156074 AAI56075 BC157039 AAI57040 BX649062 XM_005245422 XP_005245479 XM_011509857 XP_011508159 XM_011509858 XP_011508160 XM_011509859 XP_011508161 XR_921907 NM_020318 NP_064714 NM_021936 NP_068755
|
| Function |
Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. {ECO:0000269|PubMed:11264294}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Tissue Specificity |
Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. {ECO:0000269|PubMed:11264294, ECO:0000269|PubMed:11597188}.
|