Gene Symbol | PAPPA2 |
---|---|
Entrez Gene | 60676 |
Alt Symbol | PAPP-A2, PAPP-E, PAPPE, PLAC3 |
Species | Human |
Gene Type | protein-coding |
Description | pappalysin 2 |
Other Description | pappalysin-2|placenta-specific 3|pregnancy-associated plasma preproprotein-A2|pregnancy-associated plasma protein E1 |
Swissprots | A9Z1Y8 Q9BXP8 Q96PH7 Q96PH8 Q9H4C9 |
Accessions | CAD35982 CCD35052 EAW91003 EAW91004 Q9BXP8 AB209369 BAD92606 AF311940 AAK31073 AF342989 AAL17779 AF342990 AAL17780 AJ278348 CAC11134 AK096718 BC062665 BC104644 BC117193 AAI17194 BC117195 AAI17196 BC152552 BC156074 AAI56075 BC157039 AAI57040 BX649062 XM_005245422 XP_005245479 XM_011509857 XP_011508159 XM_011509858 XP_011508160 XM_011509859 XP_011508161 XR_921907 NM_020318 NP_064714 NM_021936 NP_068755 |
Function | Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. {ECO:0000269|PubMed:11264294}. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. {ECO:0000269|PubMed:11264294, ECO:0000269|PubMed:11597188}. |