PAPPA2
| Gene Symbol | PAPPA2 |
|---|---|
| Entrez Gene | 60676 |
| Alt Symbol | PAPP-A2, PAPP-E, PAPPE, PLAC3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | pappalysin 2 |
| Other Description | pappalysin-2|placenta-specific 3|pregnancy-associated plasma preproprotein-A2|pregnancy-associated plasma protein E1 |
| Swissprots | A9Z1Y8 Q9BXP8 Q96PH7 Q96PH8 Q9H4C9 |
| Accessions | CAD35982 CCD35052 EAW91003 EAW91004 Q9BXP8 AB209369 BAD92606 AF311940 AAK31073 AF342989 AAL17779 AF342990 AAL17780 AJ278348 CAC11134 AK096718 BC062665 BC104644 BC117193 AAI17194 BC117195 AAI17196 BC152552 BC156074 AAI56075 BC157039 AAI57040 BX649062 XM_005245422 XP_005245479 XM_011509857 XP_011508159 XM_011509858 XP_011508160 XM_011509859 XP_011508161 XR_921907 NM_020318 NP_064714 NM_021936 NP_068755 |
| Function | Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. {ECO:0000269|PubMed:11264294}. |
| Subcellular Location | Secreted {ECO:0000250}. |
| Tissue Specificity | Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. {ECO:0000269|PubMed:11264294, ECO:0000269|PubMed:11597188}. |
PAPP-A2 CRISPR/Cas9 KO Plasmid (h) - sc-412949 from Santa Cruz Biotechnology
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PAPP-A2 HDR Plasmid (h) - sc-412949-HDR from Santa Cruz Biotechnology
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PAPP-A2 Double Nickase Plasmid (h) - sc-412949-NIC from Santa Cruz Biotechnology
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PAPP-A2 Double Nickase Plasmid (h2) - sc-412949-NIC-2 from Santa Cruz Biotechnology
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PAPP-A2 CRISPR Activation Plasmid (h) - sc-412949-ACT from Santa Cruz Biotechnology
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PAPP-A2 CRISPR Activation Plasmid (h2) - sc-412949-ACT-2 from Santa Cruz Biotechnology
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PAPP-A2 Lentiviral Activation Particles (h) - sc-412949-LAC from Santa Cruz Biotechnology
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PAPP-A2 Lentiviral Activation Particles (h2) - sc-412949-LAC-2 from Santa Cruz Biotechnology
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PAPP-A2 siRNA (h) - sc-88175 from Santa Cruz Biotechnology
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PAPP-A2 shRNA Plasmid (h) - sc-88175-SH from Santa Cruz Biotechnology
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PAPP-A2 shRNA (h) Lentiviral Particles - sc-88175-V from Santa Cruz Biotechnology
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Pappalysin-2/PAPP-A2 RNAi - H00060676-R01 from Novus Biologicals
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MISSION® esiRNA - EHU015301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2454 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2454 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06130 from Sigma-Aldrich
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PAPPA2 siRNA (Human) - CRJ1826 from Cohesion Biosciences
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Pappalysin-2/PAPP-A2 RNAi - H00060676-R02 from Novus Biologicals
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shRNA set against Human PAPPA2 (NM_021936.2) - SHH370540 from Creative biogene
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shRNA set against Human PAPPA2(NM_020318.2) - SHR087528 from Creative biogene
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shRNA set against Human PAPPA2(NM_021936.2) - SHR087564 from Creative biogene
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Human PAPPA2 siRNA - orb272327 from Biorbyt
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PAPPA2 shRNA Plasmid (Human) - CHJ1826 from Cohesion Biosciences
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PAPPA2 miRNA 3'UTR clone - MiUTR1H-07498 from Creative biogene
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PAPPA2 miRNA 3'UTR clone - MiUTR1H-07499 from Creative biogene
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