| Gene Symbol |
MTHFS
|
| Entrez Gene |
10588
|
| Alt Symbol |
HsT19268
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
|
| Other Description |
5-formyltetrahydrofolate cyclo-ligase|methenyl-THF synthetase
|
| Swissprots |
H3BQ75 P49914
|
| Accessions |
EAW99132 P49914 AK054972 AL109717 AL110101 BC012417 AAH12417 BC019921 AAH19921 BC037852 BM313547 BM450865 CB995322 CK905549 DB464304 HG507300 L38928 AAC41945 NM_001199758 NP_001186687 NM_006441 NP_006432 NR_037654
|
| Function |
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
One carbon pool by folate
|