Gene Symbol | MTHFS |
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Entrez Gene | 10588 |
Alt Symbol | HsT19268 |
Species | Human |
Gene Type | protein-coding |
Description | 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) |
Other Description | 5-formyltetrahydrofolate cyclo-ligase|methenyl-THF synthetase |
Swissprots | H3BQ75 P49914 |
Accessions | EAW99132 P49914 AK054972 AL109717 AL110101 BC012417 AAH12417 BC019921 AAH19921 BC037852 BM313547 BM450865 CB995322 CK905549 DB464304 HG507300 L38928 AAC41945 NM_001199758 NP_001186687 NM_006441 NP_006432 NR_037654 |
Function | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}. |
Subcellular Location | Cytoplasm. |
Top Pathways | One carbon pool by folate |
Human MTHFS full length protein - ab104635 from Abcam
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Human MTHFS full length protein - ab124855 from Abcam
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HsT19268 / MTHFS Antibody Blocking Peptide - LS-E6021 from LifeSpan Bioscience
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HsT19268 / MTHFS Antibody Blocking Peptide - LS-E18741 from LifeSpan Bioscience
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HsT19268 / MTHFS Antibody Blocking Peptide - LS-E18742 from LifeSpan Bioscience
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HsT19268 / MTHFS Antibody Blocking Peptide - LS-E26687 from LifeSpan Bioscience
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MTHFS Partial Recombinant Protein - H00010588-Q01 from Novus Biologicals
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Recombinant Human MTHFS Protein - NBP1-51046 from Novus Biologicals
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MTHFS Recombinant Protein - P3574 from Novus Biologicals
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MTHFS-Antibody-C-term-Blocking-Peptide - BP18596b from Abgent, a WuXi AppTec company
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MTHFS blocking peptide - GTX88772-PEP from GeneTex
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Human MTHFS protein - orb246400 from Biorbyt
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Human MTHFS protein - orb168863 from Biorbyt
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MTHFS Blocking Peptide - 33R-9307 from Fitzgerald
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MTHFS Blocking Peptide - 33R-9306 from Fitzgerald
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MTHFS protein (His tag) - 80R-1734 from Fitzgerald
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MTHFS Peptide - AC21-1527-P from Abcore
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MTHFS (1-203, His-tag) - AR09916PU-L from Acris Antibodies
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MTHFS (1-203, His-tag) - AR09916PU-N from Acris Antibodies
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MTHFS - H00010588-Q01-10 from Acris Antibodies
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MTHFS - H00010588-Q01-25 from Acris Antibodies
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MTHFS - P3574 from Acris Antibodies
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5,10-Methenyltetrahydrofolate Synthetase, Human Recombinant - 228-12248-1 from RayBiotech
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MTHFS, 1-203aa, Human, His tag, E.coli - 01-P0976 from ARP American Research Products
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MTHFS Peptide - 46-871P from ProSci
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