| Gene Symbol | TPM4 |
|---|---|
| Entrez Gene | 7171 |
| Alt Symbol | HEL-S-108 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tropomyosin 4 |
| Other Description | TM30p1|epididymis secretory protein Li 108|tropomyosin alpha-4 chain|tropomyosin-4 |
| Swissprots | P67936 Q15659 Q9UCS4 Q9UCS1 Q9H8Q3 Q9UCS3 Q5U0D9 Q9UCS2 P07226 Q9BU85 |
| Accessions | EAW84521 EAW84522 EAW84523 EAW84524 P67936 AF186109 AAG17014 AK023385 BAB14554 AK095546 AK096732 AK300136 BAG61923 AK301285 BAG62844 AK307538 AK315076 BAG37545 BC002827 AAH02827 BC037576 AAH37576 BC067225 AAH67225 BT019634 AAV38440 DA032511 DC365500 FJ224305 ACI45997 M12127 AAA36774 X05276 CAA28888 XM_005260042 XP_005260099 XM_006722865 XP_006722928 XM_011528231 XP_011526533 XM_011528232 XP_011526534 NM_001145160 NP_001138632 NM_003290 NP_003281 |
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. {ECO:0000269|PubMed:1836432}. |
| Subcellular Location | Cytoplasm, cytoskeleton. |
| Tissue Specificity | Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). {ECO:0000269|PubMed:1836432}. |
| Top Pathways | Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes |