TPM4

Gene Symbol TPM4
Entrez Gene 7171
Alt Symbol HEL-S-108
Species Human
Gene Type protein-coding
Description tropomyosin 4
Other Description TM30p1|epididymis secretory protein Li 108|tropomyosin alpha-4 chain|tropomyosin-4
Swissprots P67936 Q15659 Q9UCS4 Q9UCS1 Q9H8Q3 Q9UCS3 Q5U0D9 Q9UCS2 P07226 Q9BU85
Accessions EAW84521 EAW84522 EAW84523 EAW84524 P67936 AF186109 AAG17014 AK023385 BAB14554 AK095546 AK096732 AK300136 BAG61923 AK301285 BAG62844 AK307538 AK315076 BAG37545 BC002827 AAH02827 BC037576 AAH37576 BC067225 AAH67225 BT019634 AAV38440 DA032511 DC365500 FJ224305 ACI45997 M12127 AAA36774 X05276 CAA28888 XM_005260042 XP_005260099 XM_006722865 XP_006722928 XM_011528231 XP_011526533 XM_011528232 XP_011526534 NM_001145160 NP_001138632 NM_003290 NP_003281
Function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. {ECO:0000269|PubMed:1836432}.
Subcellular Location Cytoplasm, cytoskeleton.
Tissue Specificity Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). {ECO:0000269|PubMed:1836432}.
Top Pathways Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes

Tropomyosin 4 CRISPR/Cas9 KO Plasmid (h) - sc-403141 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tropomyosin 4 HDR Plasmid (h) - sc-403141-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tropomyosin 4 Double Nickase Plasmid (h) - sc-403141-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tropomyosin 4 Double Nickase Plasmid (h2) - sc-403141-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tropomyosin 4 CRISPR Activation Plasmid (h) - sc-403141-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tropomyosin 4 CRISPR Activation Plasmid (h2) - sc-403141-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tropomyosin 4 Lentiviral Activation Particles (h) - sc-403141-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tropomyosin 4 Lentiviral Activation Particles (h2) - sc-403141-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

tropomyosin-4 RNAi - H00007171-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU116171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21871 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21871 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09064 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09064

TPM4 siRNA (Human) - CRH4922 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TPM4 - MBS8235725 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human TPM4 siRNA - orb265424 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TPM4 shRNA Plasmid (Human) - CHH4922 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TPM4 miRNA 3'UTR clone - MiUTR3H-03266 from Creative biogene

Species Reactivities Human

TPM4 miRNA 3'UTR clone - MiUTR3H-03267 from Creative biogene

Species Reactivities Human
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